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EC number: 204-171-4 | CAS number: 117-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- boundary composition of tetrachlorophthalic anhydride
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- boundary composition of tetrachlorophthalic anhydride
- Name:
- Tetrachlorophthalic anhydride
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- Tetrachlorophthalic anhydride
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The relevant PBT (persistent, bioaccumulative, toxic) criteria according to the REACH regulation and the corresponding properties of tetrachlorophthalic anhydride are compiled in the following Table:
PBT and vPvB criteria and the corresponding properties of tetrachlorophthalic anhydrideand its hydrolysis product tetrachlorophthalic acid
Criterion
PBT criteria
vPvB criteria
Tetrachlorophthalic anhydride
Criterion
fulfilled?P
Half-life in marine water >60 d, or
half-life in fresh- or estuarine water >40 d, or
half-life in marine sediment >180 d, or
half-life in fresh- or estuarine water sediment >120 d, or
half-life in soil >120 dHalf-life in marine, fresh or esturarine water >60 d, or
half-life in marine, fresh or esturarine sediment >180 d, or
half-life in soil >180 dTetrachlorophthalic anhydride is not readily biodegradable but it is degraded rapidly by hydrolysis having a half-life < 5 minutes at 25°C at pH 4,7 and 9. The hydrolysis product is hydrolytically stable.
Tetrachlorophthalic anhydride = No
Tetrachlorophthalic acid = Yes
B
BCF >2000
BCF >5000
Calculated BCFs of 541 and 3 indicate no bioaccumulation potential for both, tetrachlorophthalic anhydride and tetrachlorophthalic acid
No
T
Long-term NOEC for marine or freshwater organisms < 0.01 mg/l
No information available
No/yes
T
CMR
Not applicable.
Not classified as CMR
No
T
Other evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC
Not applicable
Not classified as T, R48, or Xn, R48 according to Directive 67/548/EEC
No
As a definitive conclusion on the PBT or vPvB properties, based on the criteria set down in Annex XIII of the REACH regulation cannot reached, the whole available information is taken into account, in order to decide whether the substance is to be considered as a potential PBT/vPvB substance.
The information relevant for screening for P, B, or T properties is compiled in the following table:
Screening criteria for P, vP, B, vB and T
Criterion
Type of data with its criterion
Screening assignment
Tetrachlorophthalic anhydride
Criterion fulfilled?
P
Readily biodegradable in a Ready biodegradability test
Not P and not vP
The substance is not readily biodegradable. The hydrolysis product tetrachlorophthalic acid is considered to be not readily biodegradable.
P / vP
P
Readily biodegradable in a Enhanced ready biodegradability test
Not P and not vP
No information available
P
≥ 70% mineralisation (DOC removal) within 7d; log phase no longer than 3d; removal before degradation occurs below 15%; no pre-adapted inoculum
in a Zahn-Wellens Test (OECD 302B)≥ 70% mineralization (O2 uptake) within 14 days; log phase no longer than 3d; no pre-adapted inoculum
in a MITI II test (OECD 302C)Not P
No information available
P
Does not biodegrade fast (probability < 0.5) and ultimate biodegradation timeframe prediction: ≥ months (value < 2.2)
or
Does not biodegrade fast (probability < 0.5) and ultimate biodegradation timeframe prediction: ≥ months (value < 2.2)
in Biowin 2 (non-linear model prediction) and Biowin 3 (ultimate biodegradation time)
or
in Biowin 6 (MITI non-linear model prediction) and Biowin 3 (ultimate biodegradation time)P
No information available
B
e. g. BMF >1
in Convincing evidence that a substance can biomagnify in the food chain (e. g. field data)B or vB, definitive assignment possible
No information available
B
Log Kow ≤ 4.5
in Octanol-water partitioning coefficient (experimentally determined or estimated by valid QSAR)Not B and not vB
As tetrachlorophthalic ahydride decomposes rapidly in water, the hydrolysis product tetrachlorophthalic acid is taken into account for assessment on bioaccumulative properties. A BCF of 3.16 has been calculated with the EPISuite Estimation Program (BCFWIN) taking the measured log Kow in account, indicating no significant potential for bioaccumulation.
Not B and not vB
T
EC50 or LC 50 < 0.01 mg/L
in Short-term aquatic toxicity (algae, daphnia, fish)T, criterion considered to be definitely fulfilled
72h-EC50 = 84 mg/l
Not T
T
EC50 or LC50 < 0.1 mg/L
in Short-term aquatic toxicity (algae, daphnia, fish)T
72 h-EC50 = 84 mg/l
Not T
T
NOEC < 30 mg/kg food
in Avian toxicity (subchronic or chronic toxicity or toxic for reproduction)T
No information available
Persistence Assessment
The table demonstrates that tetrachlorophthalic anhydride does not fulfil the P or vP criteria. The hydrolysis product tetrachlorophthalic acid fulfil the P or vP criteria, as the substance is considered to be not readily biodegradable, based on the result of a test on ready biodegradability using tetrachlororphthalic anhydride as test substance.
Bioaccumulation Assessment
The table demonstrates that neither tetrachlorophthalic anhydride nor its hydrolysis product tetrachlorophthalic acid do not fulfil the B or vB criteria.
Toxicity Assessment
The substance is not classified as category 1 or 2 Carcinogenic, Mutagenic or toxic to Reproduction (CMR). Regarding the screening criteria for toxicity, the acute toxicity effect concentration (L(E)50) for marine or freshwater organisms is not less than 0.01 mg/l. There are no indications of acute toxicity, and neither the substance nor its hydrolysis product show evidence of long-term toxicity. Tetrachlorophthalic anhydride and the hydrolysis product tetrachlorophthalic acid do not fulfil the criteria for T classification.
Summary and overall Conclusions on PBT or vPvB Properties
A substance is identified as a PBT substance if it fulfils all three PBT criteria described above. The B and the T criterion are not fulfilled, and therefore tetrachlorophthalic anhydride cannot be classified as PBT. This is in agreement with the statement of the PBT Working Group summarised in the ECB-Summary Fact Sheet (2007).
A substance is identified as a vPvB substance if it fulfils both vPvB criteria described above. The B criterion is not fulfilled and tetrachlorophthalic anhydride cannot be classified as vPvB.
Referenceopen allclose all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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