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EC number: 260-690-6 | CAS number: 57352-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal Irritation Assessment of Three Benzene Sulfonate Compounds
- Author:
- Chin H. Tay,Barbara T. Pugh,Stephen R. Clough and Brian H. Magee
- Year:
- 2 004
- Bibliographic source:
- International Journal of Toxicology ,January 2004 vol. 23 no. 1 pp.11-16
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Principles of method if other than guideline:
- A Skin irritation study was performed on New Zealand White rabbits to assess the irritation potential of Sodium benzene sulfonate
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium benzenesulphonate
- EC Number:
- 208-198-2
- EC Name:
- Sodium benzenesulphonate
- Cas Number:
- 515-42-4
- Molecular formula:
- C6H6O3S.Na
- IUPAC Name:
- Sodium benzene sulfonate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Sodium benzene sulfonate
Molecular Formula:C6H6O3S.Na
Molecular Weight:180.1585 g/mol
InChI:1S/C6H6O3S.Na/c7-10(8,9)6-4-2-1-3-5-6;/h1-5H,(H,7,8,9);/q;+1/p-1
Substance Type:Organic
Physical State:Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Sodium benzene sulfonate
Molecular Formula:C6H6O3S.Na
Molecular Weight:180.1585 g/mol
InChI:1S/C6H6O3S.Na/c7-10(8,9)6-4-2-1-3-5-6;/h1-5H,(H,7,8,9);/q;+1/p-1
Substance Type:Organic
Physical State:Solid
Lot Number: DU 11227LN
Purchased from: purchased from Sigma-Aldrich
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Millbrook Rabbit Breeding Labs in Amherst, MA.
- Age at study initiation:10 weeks old
- Weight at study initiation: between 2.03 and 2.24 kg
- Fasting period before study:No data
- Housing: Rabbits were housed individually in suspended stainless steel cages with noncontact hardwood chips as bedding
- Diet (e.g. ad libitum): TEK 8630 Rabbit Diet;ad libitum
- Water (e.g. ad libitum): tap water, ad libitum.
- Acclimation period:No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68 deg.F (±5 deg.F) (20deg.C)
- Humidity (%):between 30% and 70%
- Air changes (per hr): 10 to 15 air exchanges per hour
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle of full spectrum fluorescent lights
IN-LIFE DATES: From: To:No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Distillled water
- Controls:
- yes
- Amount / concentration applied:
- four doses were applied: 5000 mg/L, 2000 mg/L, 1000 mg/L, and 500 mg/l
- Duration of treatment / exposure:
- 4-hrs.
- Observation period:
- 1, 24, 48, and 72 hours after patch removal
- Number of animals:
- 6 male and 6 female per dose group
- Details on study design:
- TEST SITE
- Area of exposure: small area of skin(rabbits trunk)
- % coverage: approximately 6cm2
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the patches were
removed and the skin wiped to remove any test substance still remaining
- Time after start of exposure: At the end of the 4-hour exposure period
SCORING SYSTEM: Draize Scale for Scoring Skin Reactions (USEPA 1998)
This scale assesses irritation as follows: 0, no erythema or edema; 1, very slight erythema and/or edema (barely perceptible); 2, well-defined erythema and/or slight edema; 3, moderate to severe erythema or moderate edema, and 4, severe erythema and/or edema.
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour after patch removal
- Score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: very slight erythema was observed
- Remarks:
- dose level 5000mg/l
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour after patch removal
- Score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: very slight erythema was observed
- Remarks:
- dose level 2000mg/l
- Irritant / corrosive response data:
- At a dose of 5000 mg/L, very slight erythema (Draize Score 1) was observed in all three test animals 1 hour after removal of the gauze containing the benzene sulfonate solution. At the 24-hour observation point, very slight irritation (Draize Score 1) was observed in one of the three test animals. At the 48- and 72-hour observation points, the irritation was reversed, and no irritation was observed in any of the animals. Edema was not observed at any time. Control skin showed no signs of irritation. At 2000 mg/L, very slight erythema (Draize Score 1) was observed in two of the three test animals 1 hour after removal of the benzene sulfonate solution. The irritation was reversed by 24 hours. No erythema was observed in any test animals at this dosage at 24, 48 or 72 hours.
Any other information on results incl. tables
Table 1: Clinical Observations
Compound |
Dosagea(mg/l) |
N |
Body weight (kg)b |
Weight changeb |
Signs of toxicityc |
|
Day 0 |
Day 3 |
|||||
Benzene sulphonate |
5000 |
3 |
2.18±0.030 |
2.22±0.036 |
0.04±0.010 |
none |
Benzene sulphonate |
2000 |
3 |
2.16±0.072 |
2.20±0.066 |
0.04±0.010 |
none |
Benzene sulphonate |
1000 |
3 |
2.11±0.072 |
2.16±0.064 |
0.05±0.012 |
none |
Benzene sulphonate |
500 |
3 |
2.12±0.072 |
2.17±0.072 |
0.05±0.012 |
none |
a- Dermal application volume was 0.5 ml.
b- Values expressed as mean ± standard deviation.
c- Excluding dermal observations of erythema or edema.
Table 2: Summary of irritation tests for benzene sulphonate
Time (in hours)a |
Concentration appliedb(mg/l) |
Effects |
1 |
5000 |
Very slight or well defined erythema in all animals |
24 |
Very slight erythema in 1 of 3 animals |
|
48 |
None observed |
|
72 |
None observed |
|
Conclusion |
Slight irritant reversible in 48 hours |
|
1 |
2000 |
Mild erythema in 2 of 3 animals |
24 |
None observed |
|
48 |
None observed |
|
72 |
|
None observed |
Conclusion |
Slight irritant reversible in 24 hours |
|
1 |
1000 |
None observed |
24 |
None observed |
|
48 |
None observed |
|
Conclusion |
Not an irritant |
|
1 |
500 |
None observed |
24 |
None observed |
|
48 |
None observed |
|
Conclusion |
Not an irritant |
a- Time refers to time elapsed following the 4-hour exposure to the test substance.
b- Dermal application volume was 0.5 ml.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- At a dose of 5000 mg/L, very slight erythema (Draize Score 1) was observed in all three test animals 1 hour after removal of the gauze containing the benzene sulfonate solution .
At 2000 mg/L, very slight erythema (Draize Score 1) was observed in two of the three test animals 1 hour after removal of the benzene sulfonate solution. The irritation was reversed by 24 hours. No erythema or edema was observed in any test animals at this dosage at 24, 48 or 72 hours.
Since the effects at all dose levels were fully reversible within 72 hours, Sodium Benzene sulfonate can be considered not irritating to rabbit skin. - Executive summary:
A Skin irritation study was performed on New Zealand White rabbits to assess the irritation potential of sodium Benzene sulfonate. The study was performed according to EPA OPPTS 870.2500, “Acute Dermal Irritation” Guidelines.Four doses were applied: 5000 mg/L, 2000 mg/L, 1000 mg/L, and 500 mg/l to 6 male and 6 female rabbits per dose group. The pH of the 1000 mg/L dosage was 7.01 and 6.98 prior to dosing and after the 4-hour exposure, respectively. For the 5000 mg/L dosage, the pH was 7.00 and 7.02 prior to dosing and after the 4-hour exposure, respectively.
Each dose of test compound (0.5 ml of each concentration for each dose cohort) was applied to a small area of skin (approximately 6cm2) and covered with four layers of gauze patch held in place with nonirritating tape. Since the compound was in liquid form, it was applied to the gauze before application to the skin. The patch was loosely held in contact with the skin using a semi-occlusive dressing for the exposure period of 4 hours.
At the end of the 4-hour exposure period, the patches were removed and the skin wiped to remove any test substance still remaining. Animals were observed for signs of erythema and edema at 1, 24, 48, and 72 hours after patch removal. Observations of erythema or edema were scored according to the Draize Scale for Scoring Skin Reactions (USEPA 1998). This scale assesses irritation as follows: 0, no erythema or edema; 1, very slight erythema and/or edema (barely perceptible); 2, well-defined erythema and/or slight edema; 3, moderate to severe erythema or moderate edema, and 4, severe erythema and/or edema. Animals were weighed before exposure and at the end of the exposure period (day 3) and observed daily for the incidence of any clinical signs of toxicity (other than erythema and edema). Control skin showed no signs of irritation.
At a dose of 5000 mg/L, very slight erythema (Draize Score 1) was observed in all three test animals 1 hour after removal of the gauze containing the benzene sulfonate solution.
At the 24-hour observation point, very slight irritation (Draize Score 1) was observed in one of the three test animals. At the 48- and 72-hour observation points, the irritation was reversed, and no irritation was observed in any of the animals. Edema was not observed at any time. Control skin showed no signs of irritation. At 2000 mg/L, very slight erythema (Draize Score 1) was observed in two of the three test animals 1 hour after removal of the benzene sulfonate solution. The irritation was reversed by 24 hours. No erythema was observed in any test animals at this dosage at 24, 48 or 72 hours.
Since the effects at all dose levels were fully reversible within 72 hours, Sodium Benzene sulfonate can be considered not irritating to rabbit skin.
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