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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation/corrosion:

A weight of evidence approach has been taken based on four seperate tests (two in rats and two in rabbits).

Tests in rats:

-In rats (strain and age not provided), application of 0.1 mL of diallylamine to a 1 cm2 area of shaved abdominal skin caused severe necrosis and death.

-In rats (strain and age not provided), application of 0.1 mL of diallylamine for 1 hour under a patch caused severe necrosis followed by death.

Application of 0.05 mL had no effects.

Tests in rabbits:

-Diallylamine was corrosive on intact rabbit skin (strain, age and dose not provided) exposed for 4 hours and observed for 4, 24 and 48 hours after treatment. Severe necrosis was present at all observation points.

-Diallylamine was corrosive to rabbit skin after either a three-minute or one-hour exposure to undiluted test material (0.5 ml) under a patch.

The outcome of all available reults showed diallylamine to be corrosion to skin (rat and rabbit).

Eye irritation:

Two available tests in rabbit eyes have been used in the assessment of eye irritation.

-In rabbits (strain and age not specified), application of 50 mg diallylamine to the eyes was severely irritating. Eyes were rinsed for 20 seconds following exposure, but the duration of exposure was not specified.

-In six New Zealand White rabbits, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application of 0,1 mL diallylamine into one eye.

It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.

Based on this data the substance is considered to be a corrosive/severely irritating to the eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
0.1 mL applied to 1cm2 area
GLP compliance:
not specified
Specific details on test material used for the study:
Purity not provided.
Species:
rat
Strain:
not specified
Details on test animals or test system and environmental conditions:
rat strain and age not specified
Type of coverage:
not specified
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.1 mL applied to 1 cm2 area of shaved abdominal skin.
Duration of treatment / exposure:
Single application
Observation period:
Not provided
Number of animals:
Not provided
Remarks on result:
other: Severe necrosis and death
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritant / corrosive response data:
Exposure caused severe necrosis and death, but the incidence of mortality was not provided.
Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Exposure caused severe necrosis and death.
Executive summary:

In rats (strain and age not provided), application of 0.1 mL of diallylamine to a 1 cm2 area of shaved abdominal skin caused severe necrosis and death.

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
0.05 and 0.1 ml/sq.cm. substance applied for 1 hour under patch
GLP compliance:
no
Specific details on test material used for the study:
Purity not provided.
Species:
rat
Strain:
not specified
Type of coverage:
other: under patch
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.05 ml and 0.1 ml
Duration of treatment / exposure:
1 hour
Observation period:
Not specified
Number of animals:
Not specified.
Irritation parameter:
other: necrosis
Basis:
other: 0.10 ml application
Remarks on result:
other: Severe necrosis followed by death
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritation parameter:
other: necrosis
Basis:
other: 0.05 ml application
Remarks on result:
no indication of irritation
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritant / corrosive response data:
Severe necrosis at 0.10 ml.
No effect at 0.05 ml.
Other effects:
Death at 0.10 ml
Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Severe necrosis at 0.10 ml.
Executive summary:

In rats (strain and age not provided), application of 0.1 mL of diallylamine for 1 hour under a patch caused severe necrosis followed by death.

Application of 0.05 mL had no effects.

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Specific details on test material used for the study:
Purity not provided.
Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
Rabbit strain and age not provided.
Type of coverage:
not specified
Preparation of test site:
other: intact skin
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
Amount applied not provided.
Duration of treatment / exposure:
4 hours
Observation period:
Observations were made 4, 24, 48 hours after treatment.
Number of animals:
6
Irritation parameter:
other: necrosis
Basis:
other: all rabbits
Time point:
other: 4, 24 and 48 hours
Reversibility:
not reversible
Remarks on result:
other: corrosive
Remarks:
severe necrosis. This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritant / corrosive response data:
Diallylamine was corrosive and caused severe necrosis in the skin of all rabbits at all observation times.
Other effects:
Mortality data not provided.
Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Diallylamine was corrosive and caused severe necrosis in the skin of all rabbits at all observation times.
Executive summary:

Diallylamine was corrosive on intact rabbit skin (strain, age and dose not provided) exposed for 4 hours and observed for 4, 24 and 48 hours after treatment. Severe necrosis was present at all observation points.

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Specific details on test material used for the study:
Purity not provided
Species:
rabbit
Strain:
not specified
Type of coverage:
other: under patch
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
3 minute and 1 hour exposure
Observation period:
not specified
Number of animals:
6 (3 per exposure)
Irritation parameter:
other: corrosion
Basis:
other: all animals
Time point:
other: 3 minute exposure
Remarks on result:
other: Corrosive
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritation parameter:
other: corrosion
Basis:
other: all animals
Time point:
other: 1 hour exposure
Remarks on result:
other: Corrosive
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritant / corrosive response data:
Corrosive to skin at either exposure time.
Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Diallylamine was corrosive to rabbit skin after either a three-minute or one-hour exposure to undiluted test material under a patch.
Executive summary:

Diallylamine was corrosive to rabbit skin after either a three-minute or one-hour exposure to undiluted test material (0.5 ml) under a patch.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records

Referenceopen allclose all

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
0.1 mL diallylamine was applied into one eye of rabbit. Observations were made 1, 2, 3 and 7 days after dosing.
GLP compliance:
not specified
Specific details on test material used for the study:
Purity not provided.
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
Age and sex of rabbits not specified.
Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
Single dose.
Observation period (in vivo):
Observations were made 1, 2, 3 and 7 days after dosing.
Number of animals or in vitro replicates:
6 rabbits.
Irritation parameter:
other: corneal damage
Time point:
other: 1, 2, 3 and 7 days
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: severe corneal damage
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritation parameter:
other: chemosis
Time point:
other: 1, 2, 3 and 7 days
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: chemosis (edema of the bulbar conjunctiva)
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritation parameter:
other: conjunctiva
Remarks:
(discharge)
Time point:
other: 1, 2, 3 and 7 days
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: discharge of the conjunctivae
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritation parameter:
other: erythema
Time point:
other: 1, 2, 3 and 7 days
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: severe erythema
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Irritant / corrosive response data:
Severe corneal damage, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application.
It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.
Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
Severe corneal damage was observed. In the conjunctivae, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge were observed. There were no signs of remission 7 days after treatment.
Executive summary:

In six New Zealand White rabbits, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application of 0,1 mL diallylamine into one eye.

It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
Diallylamine was applied to rabbits eyes. Eyes were rinsed 20 seconds following exposure.
GLP compliance:
no
Specific details on test material used for the study:
Purity not provided.
Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
Rabbits strain and age not specified.
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
50 mg (0.52 mmol)
Duration of treatment / exposure:
Eyes were rinsed 20 seconds following exposure, but the duration of exposure was not specified.
Observation period (in vivo):
Not specified
Remarks on result:
other: Diallylamine was severly irritating
Remarks:
This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
Interpretation of results:
other: severely irritating
Conclusions:
Diallylamine was severly irritating to rabbit eyes.
Executive summary:

In rabbits (strain and age not specified), application of 50 mg diallylamine to the eyes was severely irritating. Eyes were rinsed for 20 seconds following exposure, but the duration of exposure was not specified.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No highly reliability data is available for respiratory irritation. However, as the substance is corrosive and inhalation is a possible exposure route, it is a reasonable assumption that the substance may also cause respiratory tract irritation when inhaled.

Justification for classification or non-classification

Skin corrosion:

Based on the available data the substance is corrosive to skin and shall be classified as a skin corrosive Category 1; H314: Causes severe skin burns and eye damage.

A sub-category classification of 1B has been assigned based on the weight of evidence study data.

This has been considered appropriate as from the available data there is conclusion evidence for corrosion after 1 hour exposure.

A corrosive result from a 3 minute exposure is available but there are no details on whether the corrosive effects were observed within 1 hr, so it is considered classification as sub-category 1A cannot be conclusively assigned.

Eye irritation:

Based on the available data the substance is considered to be corrosive to eyes and shall be classified as having irreversible effects on the eye, Category 1; H318: Causes serious eye damage.

In addition, skin corrosives can be assumed to be corrosive to eyes.

STOT-SE 3 (Respiratory tract irritaiton):

Respiratory tract irritaiton may be assumed to present a hazard but the classification for corrosivity is considered to implicitly cover the potential to cause RTI and so an additional classification for STOT-SE 3 is considered to be superfluous.