Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-442-7 | CAS number: 1852-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented guideline study on a well-defined test substance.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Water solubility:
- >= 34.9 - <= 35.5 g/L
- Temp.:
- 20 °C
- pH:
- 6.5
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test substance at 20°C is 3.52 wt% ± 0.03 wt%, 35.2 g/L ± 0.3 g/L, 0.2237 Moles/L ± 0.0016 Moles/L.
Reference
Water Solubility Results Determined by HPLC |
|||
Test Substance in Water (Supernatants) |
Equilibrium Time at 20°C (days) |
Concentration of test substance in water (wt%) |
*pH |
S20366-158-1 |
1 |
3.54 |
6.5 |
S20366-158-2 |
1 |
3.53 |
6.5 |
S20366-158-3 |
2 |
3.54 |
6.5 |
S20366-158-4 |
2 |
3.52 |
6.5 |
S20366-158-5 |
3 |
3.49 |
6.5 |
S20366-158-6 |
3 |
3.48 |
6.5 |
*pH measured as per OECD 105 requirement. |
Description of key information
The water solubility of the test material at 20 °C was assessed according to OECD Test Guideline 105 using a flask method. The water solubility is 3.52 ± 0.03 wt%, 35.2 ± 0.3 g/L, 0.2237 ± 0.0016 Moles/L.
Key value for chemical safety assessment
- Water solubility:
- 35.2 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material at 20 °C was assessed according to OECD Test Guideline 105 using a flask method.
Two vials containing ~20 wt% test substance in distilled water were placed into a constant temperature bath at 30 °C and were allowed to equilibrate for 24 hours. They were hand shaken occasionally throughout the day. The next day vials were allowed to equilibrate at 20 °C in a constant temperature bath. Also on day 2, a 2nd set of vials were placed in the 30 °C bath and removed to equilibrate at 20 °C for 2 days. On day 3, a 3rd set of vials were placed in a 30 °C bath for 24 hours and allowed to equilibrate at 20 °C for 1 day. On day 4, all six vials were removed from the constant temperature bath and centrifuged. The supernatants were collected in order to determine the concentration. The pH of the supernatants was determined using pH strips. Results indicate that the test substance is fully equilibrated within 24 hours of exposure at 20 °C.
0.02000 ± 0.0198 g of the supernatants was weighed out in a 4-dram vial and diluted in 10 mL of water. The test substance concentration was determined against external standards. A stock test substance solution was prepared by weighing 0.02 g in a 100 mL volumetric flask, dissolving it in ~3 mL methanol, and diluting to the mark with water. Serial dilutions were made in water for a set of standards ranging from 7.8 – 195 mg/L. A six-point calibration curve was constructed from the standards. Samples and standards were transferred to autosampler vials for HPLC/UV analysis. Samples were injected after standards in the sequence.
The water solubility is 3.52 ± 0.03 wt%, 35.2 ± 0.3 g/L, 0.2237 ± 0.0016 Moles/L. The test material is considered very soluble.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.