Registration Dossier
Registration Dossier
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EC number: 441-810-8 | CAS number: 116313-85-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 441-810-8
- EC Name:
- -
- Cas Number:
- 116313-85-0
- Molecular formula:
- C7H5NO5
- IUPAC Name:
- 3,4-dihydroxy-5-nitrobenzaldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- arachis oil
Results and discussion
- Mortality:
- Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: In 2 females of the 2000 mg/kg were found death 1 and 2 days p.a.. No deaths were found at 200 mg/kg. Dark straw coloured/orange discolouring of the urine, orange discolouring of the fur and orange discolouring of the tail were found in the females treate
- Gross pathology:
- Effects on organs: The abnomalities found in animals died within the study were:
lung bleedings, dark liver, dark kidneys, bleedings of the stomach lining, dark yellow discoloured paste in the stomach, orange discolouring of the stomach, bleedings of the not glandular epithels of the stomach and bleedings of the small intestine and collon. Partly white areas of the
non glandular epithels of the stomach were found in one animal treated with 2000 mg/kg wich was sacrified in the end of the study.
No abnomalities were found in the animals of the 200 mg/kg group.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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