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EC number: 221-043-3 | CAS number: 2983-37-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): sewage treatment plant Hochdahl, Germany
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 2 mg/L
- Based on:
- act. ingr.
- Initial conc.:
- 5 mg/L
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: no data
- Solubilising agent (type and concentration if used): Disponil NP 9.5EO 10PO
- Test temperature: 20±1°C
- pH: no data
- Continuous darkness: no data
TEST SYSTEM
- Culturing apparatus: conical shoulder bottle
- Number of culture flasks/concentration: 2 (inoculum blank: 4)
- Measuring equipment: iodometric oxygen measurement, Winkler method
- closed system
SAMPLING
- Sampling frequency: 7, 14, 21, 28 d
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: no
- Other: O2 control (mineral medium without inoculum and test substance)
- Solubilising agent control (mineral medium, solubilising agent, inoculum) - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 67
- Sampling time:
- 28 d
- Remarks on result:
- other: 2 mg/L test substance
- Parameter:
- % degradation (O2 consumption)
- Value:
- 67
- Sampling time:
- 28 d
- Remarks on result:
- other: 5 mg/L test substance; at the end of the test period O2 depletion was observed, thus, the result represents minimum degradation
- Results with reference substance:
- Sodium benzoate was degradednormally: 73% after 7 d, 80% after 14d, 76% after 21 d, 80% after 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- 2-Ethyl ethyl capronate was readily biodegradable in this closed bottle test.
- Executive summary:
The biodegradation of 2-Ethyl ethyl capronate (100% a.i.) was investigated in a study conducted according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test) over a period of 28 days using activated sludge sampled from a municipal sewage treatment plant as inoculum. Due to the low water solubility of the test substance, Disponil NP 9.5EO 10PO was used as solubilising agent.
The biodegradation rate was determined by measurement of O2 consumption. Inoculum blank, O2 control (mineral medium without inoculum and test substance), solubilising agent control (mineral medium, solubilising agent, inoculum) and procedural/functional control with the reference substance Sodium benzoate were performed. The test was performed with 2 and 5 mg/L test substance concentration.
The functional control reached the pass level >60% after 7 d (73%).
The biodegradation of the test substance was 67% (at 2 mg/L) and 67% (at 5 mg /L) after 28 days. However, in the 5 mg/L samples oxygen depletion was observed during the test. Thus, these values represent only minimum biodegradation.
According to the OECD guideline, the values obtained in a 14 d window would be acceptable in the Closed Bottle method if it is considered that the number of bottles necessary to evaluate the 10-d window causes the test to become too unwieldy.
The 14 d window started > 7 d; after 21 d > 60% degradation was reached. Thus, the test substance can be considered to be readily biodegradable.
Reference
|
Concentration [mg/L] |
% BOD/COD |
|||
7 d |
14 d |
21 d |
28 d |
||
Test substance |
2 |
5 |
49 |
67 |
67 |
5 |
2 |
39 |
65 |
67 (O2 depletion) |
|
Reference substance |
2 |
73 |
80 |
76 |
80 |
Oxygen consumption
|
Concentration [mg/L] |
Oxygen concentration [mg/L] |
|||
7 d |
14 d |
21 d |
28 d |
||
Test substance |
2 |
9.98 9.96 |
7.17 6.24 |
5.57 5.64 |
5.47 5.48 |
5 |
8.77 8.80 |
1.82 6.24 |
1.12 0.17 |
0.21 0.37 |
|
Reference substance |
2 |
6.55 6.72 |
6.35 6.56 |
6.66 6.21 |
6.21 6.22 |
Inoculum blank |
--- |
9.12 9.13 9.05 8.97 |
90.1 9.29 9.05 9.15 |
8.89 8.98 9.03 9.01 |
8.88 8.76 8.90 9.01 |
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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