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EC number: 240-649-9 | CAS number: 16590-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Naltrexone
- EC Number:
- 240-649-9
- EC Name:
- Naltrexone
- Cas Number:
- 16590-41-3
- Molecular formula:
- C20H23NO4
- IUPAC Name:
- (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- HPLC-UV
Test organisms
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- The test organism (P. subcapitata, strain 278/4) was originally obtained from the culture collection of algae and protozoa and is representative species of the freshwater aquatic phytoplankton.
Prior to testing, duplicate starter cultures were prepared and incubated under test conditions to obtain sufficient algal cells in exponential growth and to achieve a starting algae cell density of 1x10e+4 cells/mL.
Study design
- Test type:
- not specified
- Water media type:
- other: reverse osmosis water
- Limit test:
- no
- Total exposure duration:
- 72 h
- Post exposure observation period:
- Following incubation, the cell density of a single starter culture was established using a particle counter and confirmed manually using a haemocytometer.
Test conditions
- Hardness:
- Not specified
- Test temperature:
- 21-24°C
- pH:
- 7.77-8.55 (test start)
- Dissolved oxygen:
- Not specified
- Nominal and measured concentrations:
- Nominal: 2.56, 6.4, 16, 40 and 100 mg/L
Measured: 2.413, 5.910, 13.968, 33.431 and 77.217 mg/L - Details on test conditions:
- Incubation under 4440-8880 lux light intensity
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 77.22 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 33.434 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 59.83 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 33.434 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 57.73 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 33.434 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield
- Details on results:
- Based on geometric mean measured concentrations, the 72-h EyC50 (yield), EbC50 (biomass) and ErC50 (growth rate) values were calculated to be 57.73, 59.83 and > 77.22 mg/L respectively. The corresponding NOEC values for yield, biomass and specific growth rate after 72 hours were 33.434 mg/L respectively.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- As the measured concentrations were outside the range of 80-120% of nominal exposure concentrations of Naltrexone which is required to report the test concentrations in terms of nominal concentrations, the test concentrations therefore, were reported as geometric mean measured concentrations.
Based on geometric mean measured concentrations, the 72-h EyC50 (yield), EbC50 (biomass) and ErC50 (growth rate) values were calculated to be 57.73, 59.83 and > 77.22 mg/L respectively. The corresponding NOEC values for yield, biomass and specific growth rate after 72 hours were 33.434 mg/L respectively.
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