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EC number: 266-959-4 | CAS number: 67707-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- August 1994 to December 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- July 31, 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- July 17, 1992
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethyl 3,5,5-trimethylhexanoate
- EC Number:
- 266-959-4
- EC Name:
- Ethyl 3,5,5-trimethylhexanoate
- Cas Number:
- 67707-75-9
- Molecular formula:
- C11H22O2
- IUPAC Name:
- ethyl 3,5,5-trimethylhexanoate
- Details on test material:
- - Name of test material: 3,5,5-Trimethyl-ethyl capronate
- Physical state: colorless liquid
- Analytical purity: >90%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, D-97633 Sulzfeld
- Weight at study initiation: 2.4 - 2.6 kg
- Housing: individually
- Diet (e.g. ad libitum): Altromin 2023 diet for rabbits, ad libitum
- Water (e.g. ad libitum): tap water from an automatical watering system, ad libitum
- Acclimation period: 6 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5 (average)
- Humidity (%): 50 (average)
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light):12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated control areas on each animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 6 d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm² on dorsal area of the trunk
- Type of wrap if used: cellulose patch with test substance was applied to the test site and held in place by fixing marginally with non irritating tape (Blendern Wundpflaster, 3M). The application site was covered by a dressing (Fixomull Stretch, Fa. Beiersdorf). Access by the animal to the application site was prevented by a plastic collar.
REMOVAL OF TEST SUBSTANCE
- At the end of the exposure period the dressing, the tape with the patch and the collar were removed. Residual test substance was wiped off using wet cellulose tissue.
SCORING SYSTEM: according to OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2
- Time point:
- other: mean 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2
- Time point:
- other: mean 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean 24, 48, 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: mean 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- 1/3 animals showed slight edema (grade 2) after 1 h, which was not present any more at the 24 h observation. The same animal showed very slight erythema (grade 1) at the 1, 24, 48 and 72 h observation. An additional examination at day 6 showed full reversibility.
- Other effects:
- no general toxic effects were noted
Any other information on results incl. tables
Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 4 |
|
60 min |
0/0/1 |
0/0/2 |
24 h |
0/0/1 |
0/0/0 |
48 h |
0/0/1 |
0/0/0 |
72 h |
0/0/1 |
0/0/0 |
Average 24h, 48h, 72h |
0/0/1 |
0/0/0 |
6 d |
-/-/0 |
-/-/0 |
- = no further examinations
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study 3,5,5-Trimethyl-ethyl capronate shows a very low irritant potential to the Skin and can be regarded as not classified for Skin Irritation according to GHS criteria
- Executive summary:
In a primary dermal irritation study according to OECD guideline 404 (July 17, 1992) and EU method B.4 (July 31, 1992) 3 young adult New Zealand White rabbits were dermally exposed to 0.5 mL of undiluted 3,5,5-Trimethyl-ethyl capronate (>90% a.i.) for 4 hours to 6 cm² body surface area. Animals then were observed for 6 days. Irritation was scored by the method of Draize.
1/3 animals showed slight edema (grade 2) after 1 h, which was not present any more at the 24 h observation. The same animal showed very slight erythema (grade 1) at the 1, 24, 48 and 72 h observation. An additional examination at day 6 showed full reversibility.
Mean erythema scores from observations at 24, 48 and 72 h after patch removal were 0/0/0; mean edema scores were 0/0/1 for all three animals.
In this study, 3,5,5-Trimethyl-ethyl capronate was practically not irritating to rabbit skin.
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