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EC number: 230-660-7 | CAS number: 7250-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Sensitization by the Intracutaneous method of triethylamine in guinea pigs
- Author:
- NTRL REPORT
- Year:
- 1 986
- Bibliographic source:
- NTRL REPORT , OTS0515586, 1986.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Skin sensitization study of N,N-diethylethanamine was performed on guinea pig by Guinea pig maximization test
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Not data avaliable
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- N,N-diethylethanamine
- Details on test material:
- - Name of test material (as cited in study report): Triethylamine- Molecular formula :C6H15N- Molecular weight :101.191 g/mole- Substance type: organic- Physical state: No data available- Purity: No data available- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Triethylamine
- Molecular formula :C6H15N
- Molecular weight :101.191 g/mole
- Substance type: organic
- Physical state: No data available
- Purity: No data available
- Impurities (identity and concentrations): No data available
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:350-450g
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available - Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: 0.75% saline in deionized water
- Concentration / amount:
- 0.1% solution in 0.75% saline in deionized water
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: 0.1% solution in 0.75% saline in deionized water
- Concentration / amount:
- 0.1% solution in 0.75% saline in deionized water
- No. of animals per dose:
- 20
- Details on study design:
- Details on study design
RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:8
- Exposure period: No data available
- Test groups:20
- Control group: No data available
- Site: No data available
- Frequency of applications: No data available
- Duration: No data available
- Concentrations: 0.1% solution in 0.75% saline in deionized water
B. CHALLENGE EXPOSURE
- No. of exposures :one
- Day(s) of challenge: After3 week rest period
- Exposure period: No data available
- Test groups:20
- Control group: No data available
- Site: No data available
- Concentrations: : 0.1% solution in 0.75% saline in deionized water
- Evaluation (hr after challenge): : No data available
OTHER: 8 animals were died during study - Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 0.1% solution in 0.75% saline
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- Skin sensitization was not observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The skin sensitization study of N, N-diethylethanamine (121-44-8) was performed on guinea pig .The N, N-diethylethanamine was considered to be not skin sensitizing.
- Executive summary:
The skin sensitization study of N, N-diethylethanamine (121-44-8) was performed in 20 male albino guinea pigs.In induction phase,0.1% solution in 0.75% saline in deionized water was given by intradermal route as After 3 weeks rest period, challenge application of same concentration was given. The Observations were made after challenge application. 8 animals were died during study .No skin sensitization reaction was observed in any animal .Hence it was considered thatN, N-diethylethanamine (121-44-8) was not skin sensitizing in guinea pig.
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