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Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
Sensitization by the Intracutaneous method of triethylamine in guinea pigs
Author:
NTRL REPORT
Year:
1986
Bibliographic source:
NTRL REPORT , OTS0515586, 1986.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Principles of method if other than guideline:
Skin sensitization study of N,N-diethylethanamine was performed on guinea pig by Guinea pig maximization test
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
Not data avaliable

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethylamine
EC Number:
204-469-4
EC Name:
Triethylamine
Cas Number:
121-44-8
Molecular formula:
C6H15N
IUPAC Name:
N,N-diethylethanamine
Details on test material:
- Name of test material (as cited in study report): Triethylamine- Molecular formula :C6H15N- Molecular weight :101.191 g/mole- Substance type: organic- Physical state: No data available- Purity: No data available- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report): Triethylamine
- Molecular formula :C6H15N
- Molecular weight :101.191 g/mole
- Substance type: organic
- Physical state: No data available
- Purity: No data available
- Impurities (identity and concentrations): No data available

In vivo test system

Test animals

Species:
guinea pig
Strain:
other: Albino
Sex:
male
Details on test animals and environmental conditions:
Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:350-450g
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available - Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available

Study design: in vivo (non-LLNA)

Induction
Route:
intradermal and epicutaneous
Vehicle:
other: 0.75% saline in deionized water
Concentration / amount:
0.1% solution in 0.75% saline in deionized water
Challenge
No.:
#1
Route:
epicutaneous, occlusive
Vehicle:
other: 0.1% solution in 0.75% saline in deionized water
Concentration / amount:
0.1% solution in 0.75% saline in deionized water
No. of animals per dose:
20
Details on study design:
Details on study design
RANGE FINDING TESTS:

MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:8
- Exposure period: No data available

- Test groups:20
- Control group: No data available

- Site: No data available

- Frequency of applications: No data available

- Duration: No data available

- Concentrations: 0.1% solution in 0.75% saline in deionized water


B. CHALLENGE EXPOSURE
- No. of exposures :one
- Day(s) of challenge: After3 week rest period
- Exposure period: No data available

- Test groups:20
- Control group: No data available

- Site: No data available
- Concentrations: : 0.1% solution in 0.75% saline in deionized water

- Evaluation (hr after challenge): : No data available

OTHER: 8 animals were died during study
Positive control substance(s):
no

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
0.1% solution in 0.75% saline
No. with + reactions:
0
Total no. in group:
20
Clinical observations:
Skin sensitization was not observed
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: Not sensitizing
Conclusions:
The skin sensitization study of N, N-diethylethanamine (121-44-8) was performed on guinea pig .The N, N-diethylethanamine was considered to be not skin sensitizing.
Executive summary:

The skin sensitization study of N, N-diethylethanamine (121-44-8) was performed in 20 male albino guinea pigs.In induction phase,0.1% solution in 0.75% saline in deionized water was given by intradermal route as After 3 weeks rest period, challenge application of same concentration was given. The Observations were made after challenge application. 8 animals were died during study .No skin sensitization reaction was observed in any animal .Hence it was considered thatN, N-diethylethanamine (121-44-8) was not skin sensitizing in guinea pig.