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EC number: 220-476-5 | CAS number: 2778-96-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
Additional information
Biodegradation in water:
Predicted data for the target compound and various supporting weight of evidence studies for its closest read across substance were reviewed for the biodegradation end point which are summarized as below:
The first study was predicted data study in this the Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database, biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 301 B "Ready Biodegradability: Modified Sturm Test (CO2 evolution)" at a temperature of 22±2°C. Bacteria collected from activated sludge of the sewage treatment plant of CH 4153 Reinach on 2/6/89 was used as a test inoculum. Initial test substance conc. used in the study was 11.3 and 23.9 mg/l, respectively. The test medium was prepared according to the method described in the guideline. 2-liter flasks equipped with gas inlet and magnetic stirrers were used as the test vessels. Aeration consisted of approx. 25 ml/min air free of carbon dioxide. 1200 ml of the mineral solution with the inoculum was aerated for 24 hours in the test vessel. In 300 ml mineral solution 0.5 ml nonylphenol 10E05PO (solution of 30 mg in 100 ml bidist. Water) and 16.3 rsp. 29.9 mg of test substance were added and homogenized. This solution was given to the test vessel which was immediately connected to the CO2 traps. The biodegradation was calculated on the basis of the theoretical carbon content of the test substance and the cumulative quantities of carbon dioxide determined on the days of measurements. Determination of the initial CO2 of the 0.05 N sodium hydroxide and the C02, absorbed in the absorbers filled with 200 ml 0.05 N sodium hydroxide on the days 7, 10, 13, 17, 20, 24, 27, and 28. Blank consisted of water as specified in the guideline containing 0.5 ml of the nonylphenol 10E05PO solution. 20 mg/L with 0.5 ml of the nonylphenol 10E05PO was used as a reference substance in the study. The percentage degradation of test substance was determined to be 15 and 2% by CO2 evolution parameter in 28 days at a chemical conc. of 11.3 and 23.9 mg/l, respectively. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
The next biodegradation study was conducted in accordance with OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test) for 28 days for evaluating the percentage biodegradability of test substance. Mixed culture was used as test inoculum for the study. Inoculum was collected form waste water treatment plant. Initial test substance conc. used in the study was 5-10 mg/l based on ThOD . The percentage degradation of test substance 18 % by oxygen uptake parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical and for its read across substance, it can be concluded that the test substance can be expected to be not readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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