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Diss Factsheets
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EC number: 219-845-3 | CAS number: 2550-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted in 1972.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Irritation study in rabbits. Test material in Neantin was applied to the skin of the rabbits for 24 hours at several different concentrations: 100%, 30%, 10%, 3% and 1%. Irritation effects were observed for a period of 7 days. A second study was conducted with repeated applications at 10%, 3% and 1% each day for 7 consecutive days.
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
Test material
- Reference substance name:
- 4,7-dimethyloct-6-en-3-one
- EC Number:
- 219-845-3
- EC Name:
- 4,7-dimethyloct-6-en-3-one
- Cas Number:
- 2550-11-0
- Molecular formula:
- C10H18O
- IUPAC Name:
- 4,7-dimethyloct-6-en-3-one
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Neantin
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 100%, 30%, 10%, 3% and 1%
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Details on study design:
- Klecak, 1970
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Remarks:
- single application
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 3
- Irritant / corrosive response data:
- Study 1
3 % irritant effects weak irritation was observed on day 1 only. Scores were normal on days 2 thru 7.
30 % irritant effects irritation and secretion was observed on day 1. Weak irritation was observed on day 2, 3 and 4. Scores were normal on days 5 thru 7.
100 % irritant effects strong irritation and secretion was observed on days 1 and 2. Irritation and secretion was observed on days 3 and 4. Weak irritation was observed on days 5 and 6. Scores were normal on day 7.
Study 2
10 % irritant effects weak irritation was observed on days 1 and 2. Scores were normal on days 3 thru 7.
1 % no effects - Other effects:
- Test material in Neantin was applied to the skin of the rabbits for 24 hours at several different concentrations. Irritation effects were observed for a period of 7 days; irritation was initially observed, but was resolved within 7 days at 100% test article concentration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Irritation study in rabbits. Test material in Neantin was applied to the skin of the rabbits for 24 hours at concentrations of 1%, 3%, 10%, 30% and 100%. Irritation effects were observed for a period of 7 days. All scores were normal by day 7.
- Executive summary:
Irritation study in rabbits. Test material in Neantin was applied to the skin of the rabbits for 24 hours at concentrations of 1%, 3%, 10%, 30% and 100%. Irritation effects were observed for a period of 7 days. All scores were normal by day 7.
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