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EC number: 204-185-0 | CAS number: 117-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
The dermal irritation potential of diphenylacetic acid (CAS No: 117-34-0) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor.
Diphenylacetic acid (CAS No: 117-34-0) was estimated to be not irritating to the skin of New Zealand White rabbits.
Based on the estimated result diphenylacetic acid (CAS No: 117-34-0) can be considered to be not irritating to skin and can be classified under the category ˋNot Clssified’ as per CLP regulation.
Eye Irritation:
The ocular irritation potential of diphenylacetic acid (CAS No: 117-34-0) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor.
Diphenylacetic acid (CAS No: 117-34-0) was estimated to be highly irritating to the eyes of New Zealand White rabbits.
Based on the estimated result diphenylacetic acid (CAS No: 117-34-0) can be considered to be irritating to eye and can be classified under the category ˋ Category 2’ as per CLP regulation
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR Toolbox 3.3 and the QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): diphenyl acetic acid
- Molecular formula: C14H12O2
- Molecular weight: 212.247 g/mol
- SMILES: C(c1ccccc1)(c1ccccc1)C(O)=O
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- The test substance was applied once to skin with a patch
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed.
- Interpretation of results:
- other: not irritating
- Conclusions:
- Diphenylacetic acid (CAS No: 117-34-0) was estimated to be not irritating to the skin of New Zealand White rabbits.
- Executive summary:
The skin irritation potential of diphenylacetic acid (CAS No: 117-34-0) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor.
Diphenylacetic acid (CAS No: 117-34-0) was estimated to be not irritating to the skin of New Zealand White rabbits.
Based on the estimated result diphenylacetic acid (CAS No: 117-34-0) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((((("a"
or "b" or "c" or "d" or "e" )
and ("f"
and (
not "g")
)
)
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and "l" )
and ("m"
and (
not "n")
)
)
and ("o"
and (
not "p")
)
)
and ("q"
and "r" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aryl AND Carboxylic acid by
Organic Functional groups
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Aryl AND Carboxylic acid by
Organic Functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aryl AND Carboxylic acid by
Organic Functional groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Acid, aliphatic attach [-COOH]
AND Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND
Aliphatic Carbon, two phenyl attach [-C-] AND Aromatic Carbon [C] AND
Carbonyl, aliphatic attach [-C(=O)-] AND Miscellaneous sulfide (=S) or
oxide (=O) AND Olefinic carbon [=CH- or =C<] AND Tertiary Carbon by
Organic functional groups (US EPA)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Aromatic compound AND Carbonic
acid derivative AND Carboxylic acid AND Carboxylic acid derivative by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Shiff base
formation after aldehyde release OR AN2 >> Shiff base formation after
aldehyde release >> Specific Acetate Esters OR Non-covalent interaction
OR Non-covalent interaction >> DNA intercalation OR Non-covalent
interaction >> DNA intercalation >> DNA Intercalators with Carboxamide
Side Chain OR Radical OR Radical >> Radical mechanism via ROS formation
(indirect) OR Radical >> Radical mechanism via ROS formation (indirect)
>> Nitroaniline Derivatives OR Radical >> Radical mechanism via ROS
formation (indirect) >> Nitrophenols, Nitrophenyl Ethers and
Nitrobenzoic Acids OR Radical >> Radical mechanism via ROS formation
(indirect) >> p-Substituted Mononitrobenzenes OR SN1 OR SN1 >>
Nucleophilic attack after carbenium ion formation OR SN1 >> Nucleophilic
attack after carbenium ion formation >> Specific Acetate Esters OR SN1
>> Nucleophilic attack after reduction and nitrenium ion formation OR
SN1 >> Nucleophilic attack after reduction and nitrenium ion formation
>> Nitroaniline Derivatives OR SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation >> Nitrophenols, Nitrophenyl
Ethers and Nitrobenzoic Acids OR SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation >> p-Substituted Mononitrobenzenes
OR SN2 OR SN2 >> Acylation OR SN2 >> Acylation >> Specific Acetate
Esters OR SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >>
Nucleophilic substitution at sp3 Carbon atom >> Specific Acetate Esters
by DNA binding by OASIS v.1.3
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Lysine peptide depletion
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Low reactive OR Low reactive >>
Organic disulfides OR Moderate reactive OR Moderate reactive >>
Unsaturated carboxylic acid anhydrides by DPRA Lysine peptide depletion
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup OR Non binder, impaired OH or NH2 group OR
Non binder, MW>500 OR Non binder, non cyclic structure OR Strong binder,
OH group OR Weak binder, OH group by Estrogen Receptor Binding
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 16
- Oxygen O by Chemical elements
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Group 1 - Alkali Earth
Li,Na,K,Rb,Cs,Fr OR Group 15 - Nitrogen N OR Group 15 - Phosphorus P OR
Group 16 - Sulfur S OR Group 17 - Halogens Br OR Group 17 - Halogens Cl
OR Group 17 - Halogens F OR Group 17 - Halogens F,Cl,Br,I,At by Chemical
elements
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Aromatic compound AND Carbonic
acid derivative AND Carboxylic acid AND Carboxylic acid derivative by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Alkylarylether OR Diarylether OR
Ether by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "q"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.76
Domain
logical expression index: "r"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.78
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR Toolbox 3.3 and the QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): diphenyl acetic acid
- Molecular formula: C14H12O2
- Molecular weight: 212.247 g/mol
- SMILES: C(c1ccccc1)(c1ccccc1)C(O)=O
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
- Vehicle:
- other: polyethylene glycol 400
- Controls:
- other: untreated eye served as control
- Amount / concentration applied:
- 100 mg test substance mixed with 0.1 ml polyethylene glycol 400
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Severe irritation was obseved.
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Diphenylacetic acid (CAS No: 117-34-0) was estimated to be highly irritating to the eyes of New Zealand White rabbits.
- Executive summary:
The ocular irritation potential of diphenylacetic acid (CAS No: 117-34-0) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor.
Diphenylacetic acid (CAS No: 117-34-0) was estimated to be highly irritating to the eyes of New Zealand White rabbits.
Based on the estimated result diphenylacetic acid (CAS No: 117-34-0) can be considered to be irritating to eye and can be classified under the category ˋ Category 2’ as per CLP regulation
Reference
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a"
or "b" or "c" or "d" or "e" )
and ("f"
and (
not "g")
)
)
and "h" )
and ("i"
and (
not "j")
)
)
and ("k"
and (
not "l")
)
)
and ("m"
and (
not "n")
)
)
and ("o"
and "p" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aryl AND Carboxylic acid by
Organic Functional groups
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Aryl AND Carboxylic acid by
Organic Functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aryl AND Carboxylic acid by
Organic Functional groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Acid, aliphatic attach [-COOH]
AND Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND
Aliphatic Carbon, two phenyl attach [-C-] AND Aromatic Carbon [C] AND
Carbonyl, aliphatic attach [-C(=O)-] AND Miscellaneous sulfide (=S) or
oxide (=O) AND Olefinic carbon [=CH- or =C<] AND Tertiary Carbon by
Organic functional groups (US EPA)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Aromatic compound AND Carbonic
acid derivative AND Carboxylic acid AND Carboxylic acid derivative by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Shiff base
formation after aldehyde release OR AN2 >> Shiff base formation after
aldehyde release >> Specific Acetate Esters OR Non-covalent interaction
OR Non-covalent interaction >> DNA intercalation OR Non-covalent
interaction >> DNA intercalation >> DNA Intercalators with Carboxamide
Side Chain OR Radical OR Radical >> Radical mechanism via ROS formation
(indirect) OR Radical >> Radical mechanism via ROS formation (indirect)
>> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR Radical >>
Radical mechanism via ROS formation (indirect) >> p-Substituted
Mononitrobenzenes OR SN1 OR SN1 >> Nucleophilic attack after carbenium
ion formation OR SN1 >> Nucleophilic attack after carbenium ion
formation >> Specific Acetate Esters OR SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation OR SN1 >> Nucleophilic attack
after reduction and nitrenium ion formation >> Nitrophenols, Nitrophenyl
Ethers and Nitrobenzoic Acids OR SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation >> p-Substituted Mononitrobenzenes
OR SN2 OR SN2 >> Acylation OR SN2 >> Acylation >> Specific Acetate
Esters OR SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >>
Nucleophilic substitution at sp3 Carbon atom >> Specific Acetate Esters
by DNA binding by OASIS v.1.3
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Non-Metals by Groups of elements
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Alkali Earth OR Halogens OR
Metals OR Transition Metals by Groups of elements
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 16
- Oxygen O by Chemical elements
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Group 15 - Nitrogen N OR Group
15 - Phosphorus P OR Group 16 - Sulfur S by Chemical elements
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Not categorized by Repeated dose
(HESS)
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as 3-Methylcholantrene
(Hepatotoxicity) Alert OR Methyldopa (Hepatotoxicity) Alert by Repeated
dose (HESS)
Domain
logical expression index: "o"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.87
Domain
logical expression index: "p"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.78
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
In different studies, diphenyl acetic acid has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with predicted data for target chemical and its functionally similar read across substances, 4-Tert-Butylbenzoicacid [CAS: 98-73-7] and Benzoic acid [CAS: 65-85-0]. The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated fordiphenyl acetic acid. Diphenyl acetic acidwas not irritating to New Zealand White rabbit skin.
Skin irritation effects were also estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used within Danish QSAR database for diphenyl acetic acid. Based on estimation, no severe skin irritation effects were known when diphenyl acetic acid was exposed to rabbit skin.
Results from both estimations indicate the possibility of diphenyl acetic acid being not irritating to skin.
The above results are further supported by the experimental study summarized in GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn), 2017; for thefunctionally similar read across substance, 4-Tert-Butylbenzoicacid [CAS: 98-73-7]. The study was performed on 6 New Zealand albino rabbits in accordance with EU test guideline B4.
Single application of 500 mg of 4-tert-butylbenzoic acid moistened with water was applied to a clipped area of 6 New Zealand albino rabbits and was held in contact with the skin for 4 hours by a semi occlusive dressing. The skin reactions were read at1, 24, 48, and 72 hours after the removal of the dressing. No cutaneous reaction was detected. Hence, 4-Tert-butylbenzoic acid was considered to be not irritating to the rabbit’s skin.
These results are further supported by the experimental study summarized in BENZOATES-SIDS Initial Assessment Report for 13th SIAM- OECD SIDS- (Bern, 7th - 9th November 2001);thefunctionally similar read across substance, Benzoic Acid [CAS: 65-85-0]. Undiluted 500mg of benzoic acid was applied to inner side of the ear of 2 rabbits under semi occlusion conditions for 24 hours. Since the chemical failed to induce any skin reaction, Benzoic acid(CAS No: -65-85-0) was considered to be not irritating to the rabbit’s skin.
Another study was performed (SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) -21 June 2005- SCCP/0891/05) on humans to assess the dermal irritation potential ofthe functionally similar substance, Benzoic Acid [CAS: 65-85-0].2% benzoic acid in petrolatum was applied to the intact skin of healthy volunteers and exposed for 46 hours. None of the volunteers exhibited any signs of irritation after 46 hours. Hence, Benzoic acid(CAS No: -65-85-0) was considered to be not irritating to the human skin.
Based on the available data for the target and read across substances and applying the weight of evidence approach, diphenyl acetic acid can be considered to be not irritating to skin.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Eye Irritation:
In different studies, diphenyl acetic acid has been investigated for potential for ocular irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with predicted data for target chemical and its functionally similar read across substances, Benzoic acid [CAS: 65-85-0] and 3-Hydroxy-2 -naphthalenecarboxylic acid [CAS: 92-70-6]. The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the ocular irritation potential was estimated fordiphenyl
acetic acid. Diphenyl acetic acidwas highly irritating to New Zealand White rabbit eyes.
This result is supported by the experimental study summarized in SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) -21 June 2005- SCCP/0891/05; for the functionally similar substance, Benzoic Acid [CAS: 65-85-0].The study was performed in accordance with EEC test method B.5, Annex V of EEC Directive 84/449/EEC. 77 mg of Benzoic acid (as a fine powder) was instilled into the right conjunctival sac of 3 female New Zealand albino rabbits (single application). After application, the lids of the treated eye were held closed for approximately two seconds. The untreated left eye served as a control. The degree of eye irritation was evaluated at immediately after dosing, 1, 24, 48 and 72 hours and 7, 14 and 21 days after treatment. The mean Draize scores were classified according to Kay and Calandra rating for eye irritation.After 60 min, Animal 1 showed no reaction to light, with translucent corneal opacity and iridial injection. The other 2 also had slight corneal opacity. All 3 had moderate chemosis and slight conjunctival redness. The corneal opacity noted in the first animal increased to nacreous areas. This persisted for 72 h. The translucent areas of opacity persisted up to Day 21. In Animal 2, the slight corneal opacity also persisted up to Day 21, but was resolved in Animal 3 by Day 7. By Day 14, in Animal 1, the iridial injection was resolved but no reaction to light. Animal 2 showed iridial injection on Day 2. The slight conjunctival redness in all animals increased to severe with a white/grey discolouration. It persisted in Animals 1 and 2 up to Day 21 and in Animal 3 to Day 7. The chemosis decreased slowly. In Animals 1 and 2, it was not completely resolved by Day 21 but it was resolved in Animal 3 by Day 14. The animals did not show any symptoms of systemic intoxication.
The estimated Draize score of 35 (60 min) is classed as severely irritating according to Kay and Calandra.
Based on these observations and score, Benzoic acid (CAS No: -65-85-0) was considered to be an eye irritant to the female New Zealand albino rabbit.
The above results are also supported by the experimental study summarized in OECD SIDS- SIDS Initial Assessment Report For SIAM 19- Berlin, Germany; 19-22 October 2004; for the functionally similar read across substance, 3-Hydroxy-2-naphthalenecarboxylic acid [CAS: 92-70-6]. The study was performed in accordance with OECD 405 guidelines. 3 -hydroxy-2 -napthalenecarboxylic acid was instilled into the each animal’s eye for 1 hour. The treated eyes were observed for signs of irritation at 24,48, 72 hours and 7,14 days.The moistened test substance caused serious damage to the eyes of rabbits. 1 hour after application, swelling and conjunctival injections as well as secretion (clear, tinted by the test substance) were observed in all three animals. At 24, 48 and 72 hours, conjunctivitis and diffuse corneal opacities were found. One animal showed iritis at 24 and 48 hours. At 7 days after the application, corneal erosion and vascularization were observed in all animals. The effects were not reversible until study end (14 days after treatment). One animal showed iritis at 24 and 48 hours. The Mean Draize scores (24-72 h): corneal opacity: 1.1, iris: 0.2, conjunctivitis: 1.9, conjunctival swelling: 1.3. At 7 days after the application, corneal erosion and vascularization were observed in all animals. The effects were not reversible until study end (14 days after treatment).
Based on the irreversible eye damage caused by 3-Hydroxy-2 naphthalenecarboxylic acid(CAS No: -92-70-6), it can be considered as severe eye irritant.
Based on the available data for the target and read across substances and applying the weight of evidence approach, diphenyl acetic acid can be considered to be severly irritating to eyes.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2”.
Justification for classification or non-classification
Available data for diphenyl acetic acid suggests that it is not likely to cause any irritation to skin and but it causes eye irritation.
Hence, diphenyl acetic acid can be classified under the category “Not Classified” for Skin and “Category 2” for eyes as per CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.