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Diss Factsheets
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EC number: 204-473-6 | CAS number: 121-47-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- Guidelines for 28-Day Repeat Dose Toxicity Testing for Chemicals (Japan)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminobenzenesulphonic acid
- EC Number:
- 204-473-6
- EC Name:
- 3-aminobenzenesulphonic acid
- Cas Number:
- 121-47-1
- Molecular formula:
- C6H7NO3S
- IUPAC Name:
- 3-aminobenzene-1-sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): 3-Aminobenzenesulfonic acid
- Purity : 98.6%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% CMC-Na solution
- Duration of treatment / exposure:
- 28 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100, 300, 1000 mg/kg/day
Basis:
actual ingested
- No. of animals per sex per dose:
- 7 (100, 300 mg/kg)
14 (0, 1000 mg/kg; 7 animals were used for 14 day recovery)) - Control animals:
- yes, concurrent vehicle
- Details on study design:
- Terminal kill: Day 29 or 43
Examinations
- Observations and examinations performed and frequency:
- CLINICAL SIGNS: Yes
BODY WEIGHT: Yes
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): yes
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Yes
HAEMATOLOGY: Yes
BLOOD CHEMISTRY: Yes
URINALYSIS: Yes - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
ORGAN WEIGHT: YES
HISTOPATHOLOGY: Yes
Results and discussion
Results of examinations
- Details on results:
- Water consumption increased in males of the 1000 mg/kg group during the late phase of administration. Decreased urinary pH values were noted in both sexes receiving 1000 mg/kg. These changes disappeared by 14 days after withdrawal. No effects were observed in terms of clinical signs, body weighs, food consumption, hematology, blood chemistry, organ weights, and autopsy or histopathology findings.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 300 mg/kg bw/day (actual dose received)
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.