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EC number: 241-318-1 | CAS number: 17283-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 2016 - January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one
- EC Number:
- 241-318-1
- EC Name:
- 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one
- Cas Number:
- 17283-81-7
- Molecular formula:
- C13H22O
- IUPAC Name:
- 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one
- Reference substance name:
- rel-4-((1R,6R)-2,2,6-trimethylcyclohexyl)butan-2-one
- Cas Number:
- 60761-23-1
- Molecular formula:
- C13H24O
- IUPAC Name:
- rel-4-((1R,6R)-2,2,6-trimethylcyclohexyl)butan-2-one
- Test material form:
- liquid
Constituent 1
impurity 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples from the test solutions were analysed to determine actual levels of the test item at start of the exposure period (time 0) and following 72 hours of exposure. At time 0 hours the measured concentrations range between 87-114% of the expected concentrations following dilution of the water saturated solution. After 72 hours exposure, the test concentrations remained stable at between 80-103% of the time 0 hours starting concentration. Therefore, the test item concentration based on initial measured concentration remained stable within ±20% throughout the exposure period.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The study was conducted under static conditions; i.e., the test solutions were not renewed during the test.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 21.0-22.1, mean 21.54 °C; for details see section 18.1 in the attached report
- pH:
- 8.3 in the test medium
8.2-9.2 in the test solutions - Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.38 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.275 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.187 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 4.73 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.48 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The EC50 based on YIELD of Pseudokirchneriella subcapitata was determined to be 9.58% of a saturated solution at a loading of 100 mg/L, equivalent to 3.38 mq Dihvdro lonone Beta/L based on measured concentrations.
The NOEC for YIELD based on nominal concentration was 0.874 % of a saturated solution at a loading of 100 mg/L, equivalent to 0.275 Mg Dihydro lonone Beta/L based on measured concentrations.
The EC50 based on GROWTH RATE of Pseudokirchneriella subcapitata was determined to be 29.0% of a saturated solution at a loading of 100 mg/L, equivalent to 10.0 mg Dihvdro lonone Beta/L based on measured concentrations.
The NOEC for GROWTH RATE based on nominal concentration was 6.61 % of a saturated solution at a loading of 100 mg/L, equivalent to 2.48 Mg Dihydro lonone Beta/L based on measured concentrations.
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