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Diss Factsheets
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EC number: 231-115-6 | CAS number: 7440-05-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Brief abstract, limted reporting. Also, the study has several deviations (e.g. inappropriate route, single dose, no positive control) and does not meet the acceptence critiera listed in the current OECD Test Guideline (478)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dominant lethal study in mice to detect mutagenic potential (usually as a result of chromosome aberrations). Treated males were housed with 3 untreated, virgin females/week for 6 consecutive weeks. Mating ability, impregnating ability, viable embryos and percent early deaths were assessed.
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- Palladium
- EC Number:
- 231-115-6
- EC Name:
- Palladium
- Cas Number:
- 7440-05-3
- Molecular formula:
- Pd
- IUPAC Name:
- palladium(2+)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- No further details reported in brief abstract.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No details reported in brief abstract.
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- Saline (suspension)
- Details on exposure:
- Single subcutaneous injection of 100 mg powdered material as a suspension in saline (1 ml)
- Duration of treatment / exposure:
- n/a
- Frequency of treatment:
- Single dose administered
- Post exposure period:
- [Presumably] 6 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg
Basis:
other: nominal in saline
- No. of animals per sex per dose:
- 10 males
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- no data
Examinations
- Tissues and cell types examined:
- Dominant lethal mutations were measured as the percentage of all implants that resulted in early death in utero (i.e. percentage resorptions).
- Evaluation criteria:
- Early (in utero) deaths as a percentage of all implants were compared in treated and control animals
- Statistics:
- None reported
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Remarks:
- Mortality and behavioural assessment only
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Additional information on results:
- Numbers of viable embryos: 10.4-11.7 and 10.2-11.5 in control groups; 11.1-11.9 in treated animals.
Percentage early deaths: 3.0-6.7 and 4.8-8.1 in control groups; 4.2-8.6 in treated group
Any other information on results incl. tables
Observations, viable embryo numbers, percentage of early deaths as a proportion of implantations did not differ between treated and control animals.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
In a limited dominant lethal mutation assay, no evidence of genotoxicity was seen following a single subcutaneous injection of powdered elemental palladium to male mice prior to mating with untreated females. - Executive summary:
In a limited non-guideline pre-GLP study, elemental palladium was tested for its ability to induce heritable genetic damage (usually indicative of chromosome aberrations) in a dominant lethal mutation assay in albino mice. Single subcutaneous injections of 100 mg powdered palladium in saline (1 ml) were given to 10 males before housing with 3 untreated, virgin females/week for 6 consecutive weeks. The percentage of implants that resulted in early foetal deaths (in utero) did not differ from those measured in saline-treated controls.
In conclusion, a mutagenic effect (indicative of chromosome aberrations) was not indicated for elemental palladium under the conditions of this limited dominant lethal mutation assay in mice.
Its worth noting, that the study has several deviations (e.g. inappropriate route, single dose, no positive control) and does not meet the acceptence criteria listed in the current OECD Test Guideline (478)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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