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EC number: 440-240-7 | CAS number: 1282554-35-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-02-21 to 2012-03-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study according to OECD study 2011 (2004)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- (1998)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
- IUPAC Name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Molecular formula (if other than submission substance): C19H20N4*1 H20- Molecular weight (if other than submission substance):322.4 - Storage condition of test material: in tighly closed container at ambient temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)- Method: The test was performed using concentrations of 0.04, 0.08, 0.16,0.25.0.38, 0.56 mg/L (diluting factor 8, 16, 32, 50, 76, 112).- Controls: yes- Chemical name of vehicle (organic solvent, emulsifier or dispersant): acetone- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 112 µL/L used in control groups
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM- Common name: Daphnia Magna- Strain/clone: breed of 62 D.M.- Source: Chinese Center of Desease Control and Prevention (Bejing, China) - Age of parental stock (mean and range, SD): aged less than 24 h at the start of the test, individuals of later than the first batch is used- Feeding during test: yes- Food type: Dry powder of Scenedsmus sp., - Amount:0.15 mg Carbon /day/Daphnia magna- Frequency: daily-Light: 16 hours light
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- no data
- Test temperature:
- within a range: 19.4 - 21.0 °C
- pH:
- within the range of pH 7.25-7.49
- Dissolved oxygen:
- within a range of 7.89- 8.49 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal: 0.04, 0.08, 0.16,0.25.0.38, 0.56 mg/L Average acutal conc.: 0.072; 0.116; 0.187; 0.270; 0.506; 0.631 mg/L
- Details on test conditions:
- TEST SYSTEM10 animals individually held at each test concentration and at least 10 animals individually held in the control series- Test vessel: 100mL- Aeration: no- Renewal rate of test solution (frequency/flow rate): every 48 h during the test and time of change was rcorded- No. of organisms per vessel: 1 Fo of less than 24 h- No. of vessels per concentration (replicates): 10- No. of vessels per vehicle control (replicates): 10- Biomass loading rate: 1 F0/100 mLTEST MEDIUM / WATER PARAMETERSM4 MediumOTHER TEST CONDITIONS- Adjustment of pH: no- Photoperiod: 16 hours light, 8 hours dark- Light intensity:of 1800 - 2300 LUXEFFECT PARAMETERS MEASURED (with observation intervals if applicable) : birth of F1 time and number; mortality of Fo; temperature of the dilution; dissovled oxygen and pH values; content of test substance in dilutonVEHICLE CONTROL PERFORMED: yesRANGE-FINDING STUDYnot data
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.08 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.04 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- other: MATC , max allowable toxicant concentration, China
- Effect conc.:
- 0.057 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Reported statistics and error estimates:
- Significance of difference in terms of biological effect corresponding to treatments (including controls) is compared by using data processing software DPS© following the route of “Experimental statistics - Completely randomized design - One-way ANOVA - Duncan Method”
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC and LOEC were found to be 0.04 mg/L and 0.08 mg/L, respectively, and the MATC was calculated to be 0.057 mg/L
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