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EC number: 213-138-3 | CAS number: 926-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
-Skin irritation/corrision: 1,3-dichlorobut-1-ene is corrosive to the skin of rabbits (Du Pont 1999, 1970, no guidelines followed)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Additional information
OECD SIDS, 2007:
Skin Irritation
1,3-dichlorobut-1-ene was not a corrosive substance in the in vitro International CorrositexTM assay (DuPont, 1999a). A follow-up in vivo study was conducted in one rabbit to confirm this result. Two sites were tested, one for 3 minutes and one for one hour. At the skin site treated for 3 minutes with 1,3-dichlorobut-1-ene, mild erythema, but no edema was noted. At 24 hours after test substance removal, moderate erythema and moderate edema were observed. At 48 and 72 hours after test substance removal, moderate erythema and severe edema were observed. After a 1-hour exposure, moderate erythema and severe edema were observed. Necrosis, severe erythema, severe edema, and a raw spot were observed at 24, 48, and 72 hours after test substance removal. Microscopic examination of the 3-minute test site revealed multifocal minimal ulceration with degeneration of adjacent collagen and diffuse mild epidermal hyperplasia. Microscopic examination of the 1-hour test site revealed severe transmural necrosis with hemorrhage and edema (DuPont, 1999b). Similar results were observed in a 24-hour dermal irritation study with rabbits (DuPont, 1970).
Studies in Humans
On human epidermis, 1,3-DCB caused an itching and burning sensation in 3 minutes. At 6 minutes, the itching and burning sensation had vanished and there was no skin inflammation (Roubal and Pokorny, 1943). No information on the exposure conditions, number of individuals tested, or test substance purity were available. In contrast to this report, current plant site experience indicates that 1,3-DCB is irritating and corrosive to human skin. Eye Irritation No eye irritation studies were identified with 1,3-DCB but based on its corrosivity, 1,3-DCB is likely to be severely irritating to the eyes.
Conclusion
1,3-DCB is corrosive to the skin of rabbits. Occupational experience shows that 1,3-DCB is also irritating and corrosive to the skin, and that 1,3-DCB vapour is irritating to the eyes and respiratory tract. No eye irritation studies were identified with 1,3-DCB but based on its corrosivity, 1,3-DCB is likely to be severely irritating to eyes
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
On the basis of the test results, 1,3-dichlorobut-2 -ene should be classified as C, R34 according to DSD classification criteria and Skin Corr. 1B, H314 (Causes severe skin burning) according to CLP classification criteria.
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