Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-555-0 | CAS number: 15520-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the findings of this OECD 404 study in New Zealand White rabbits with 4h semi occlusive skin treatment, observed over a period of 7 days, test substance is determined to be skin irritant.
Based on the findings of this OECD 405 study in New Zealand White rabbits, the test substance is determined to be highly eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
Twenty four hours prior to treatment, 25cm2of the dorsal skin was shaved. Only animals with intact skin were used. A plaster containing a cellulose layer of 2.5 x 2.5 cm was fixed on the prepared skin area of each animal. Under this plaster 0.5 mL of the undiluted test item was applied. The area was then fixed by a semi occlusive bandage for a period of 4 hours. At the end of treatment time the remaining residues were carefully deleted from skin with lukewarm water. The assessment was performed 30-60 minutes, 24, 48 and 72 hours after removing of bandage. Due to some findings still available after 72 hours, the observation period was expanded to 7 days for another evaluation. The skin was assessed for erythema-, eschar-formation and edema according to Draize. All other skin changes were noted.30-60 minutes, 24, 48 and 72 hours after removing of the plaster, slight to mild erythema and slight edema were observed at all animals.The skin appears partly dry, rough and kind of flaky during the observation period.The overall scoring value is 2.3 for erythema-, eschar-formation and 0.5 for edema formation. All findings were reversible within seven days after removal of plaster.
Eye Irritation
In order to assess the eye irrtating potential of the test substance, 0.1 mL of the undiluted test item was applied into the conjunctival sac of the left eye of one rabbit. The untreated eye serves as control. 24 hours after treatment and at any time point when the cornea needs to be inspected with fluorescein-sodium solution, the eye was washed with physiological saline solution (Temperature about 37°C). The assessment was performed 60 minutes, 24, 48 and 72 hours after application of test item and additionally after 7 days due to some findings. At the 24 and 72 hour time point and after 7 days, additionally a drop of fluorescein-sodium solution was instilled and the eye was examined under UV-light. The eye reactions were assessedaccording to the numerical scoring system (acc. to Draize). The description of the degree and nature of irritation, the presence of serious lesions and non-occular effects were noted.
Until 72 hours after application the conjunctiva showed a crimson up to diffuse strong red color and an edema up to half eye-lid closure. The iris was reddened. The cornea showed diffuse to pearly-like opacity areas. Additional a clear-colorless or white to mucous effluent and bleeding of the nictitating membrane was observed. Seven days after the application of test item the conjunctiva showed still a diffuse crimson color and the cornea diffuse opacity areas. Additional an advanced vascularization was observed.
Justification for selection of skin irritation / corrosion endpoint:
only available study
Justification for selection of eye irritation endpoint:
only available study
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Classified as:
Skin irritation Cat 2: H 315 (causes skin irritation)
Eye damage Cat 1: H 318 (causes seirous eye damage)
Justification:
Based on the findings of this OECD 404 study in New Zealand White rabbits with 4h semi occlusive skin treatment, observed over a period of 7 days, test substance is determined to be skin irritant.
Based on the findings of this OECD 405 study in New Zealand White rabbits, the test substance is determined to be highly eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.