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EC number: 248-492-8 | CAS number: 27489-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-04-22 - 199-07-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- Adopted 1984-4-4
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
- Reference substance name:
- trans-4-aminocyclohexan-1-ol
- EC Number:
- 248-492-8
- EC Name:
- trans-4-aminocyclohexan-1-ol
- Cas Number:
- 27489-62-9
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 4-aminocyclohexanol
Constituent 1
- Specific details on test material used for the study:
- Description: white powderbatch 722Purity: not indicated by sponsor; treated as 100% pureTest substance storage: at room tempearture in the darkExpiry date: 2000-04-08 (allocated by NOTOX, 1 year after receipt of the test substance)
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Crustacea, Cladocera, Straus 1820
Study design
- Test type:
- static
- Water media type:
- other: M7
- Remarks:
- see report
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250mg/L expressend as CaCO3
- Test temperature:
- 18-22°C, constant within +-1°C
- pH:
- 9.7 (T=0h); 8.2 (T=48h)
- Dissolved oxygen:
- 9.2mg/L (T=0h); 8.4mg/L(T=48h)
- Salinity:
- see report
- Nominal and measured concentrations:
- 100mg/L
- Details on test conditions:
- Test vessels : 100mL, all-glassMedium: ISO, prepared in milli-RO-waterNumber of daphnia: 20 per concentrationLoading. 10 per vessel containing 80mL mediumLight. 16h photoperiod dailyFeeding: no feedingAeration: No aeration of the test solutionIntroduction of daphnids: within 20min after preparation of the test solutions.
- Reference substance (positive control):
- yes
- Remarks:
- The reference test was carried out to check the sensitivity of the test system as used by NOTOX. Daphnia were exposed for a maximum of 48h to K2Cr2O7 concentrations of 0.1, 0.18, 0.32, 0.56, 1.0 and 1.8 mg/L and to a blank control.
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Conc. based on:
- test mat.
- Results with reference substance (positive control):
- The actual responses in this reference test with K2Cr2O7 are within the ranges of the expected responses at the different concentrations. Hence, the sensitivity of this batch of D. magna was in agreement with the historical data collected at NOTOX
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present test, trans-4-Aminocyclohexanol induced no effects in Daphnia magna exposed to a concentration of 100mg/L. Hence, the 48h-EC50 for mobility of Daphnia magna was above 100mg/L, the maximum concentration to be tested.
- Executive summary:
Trans-4 -Aminocyclohexanol was completely solible at the concentration tested. A limit test was performed exposing daphnids to a trans-4 -Aminocyclohexanol concentration of 100mg/L and a blank-control. The test considered of two vessels per group containing 10 daphnids per vessel. The study did not include sampling for determination of actual exposure concentrations.
Trans-4 -Aminocyclohexanol induced no effects in Daphnia magna exposed to a concentration of 100mg/L. Hence, 48h-EC50 for morbility of Daphnia magna was above 100mg/L, the maximum concentration to be tested
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