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EC number: 219-969-8 | CAS number: 2587-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral
LD50> 4000 mg/kg rat (male/female), Günzel & Richter (1968)
LD50 28 641.6 mg/kg rat (male), Klimmer (1970)
Inhalation
LC50 250 mg/m³, rat (male/female), Sachsse & Ullmann (1974)
Intraperitoneal
LD50 325 mg/kg, rat (male/female), Günzel & Richter (1969)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study does not specify any particular guidelines but was conducted to sound scientific principles; possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results. The study report is in German.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The methodology used was similar to that outlined in OECD Guideline 401 (Acute Oral Toxicity). A limit dose of the test material was administered to male and female rats.
- GLP compliance:
- no
- Remarks:
- Study conducted in 1968, prior to introduction of GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 90 to 120 g
- Acclimation period: 6 days - Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 g CMC in 100 mL distilled water
- Details on oral exposure:
- - Formualtion: Emulsion
- Substance concentration: 40 g in 100 mL - Doses:
- 1 dose at 4.0 g/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 12 days
- Necropsy of survivors performed: Yes. The following regions of the body were examined using the appropriate aids (e.g. magnifying glass, stereomicroscope, instruments): coat and skin, eyes, nose, mouth, ear, anus, preputial, vulva, subcutaneous tissue, stomach, pelvic cavity and peritoneum, oesophagus, small intestine, colon, mesenteric lymph nodes, liver, pancreas, spleen, kidneys, bladder, seminal vesicle, prostrate, testicle, epididymis, ovary, uterus, vagina*, chest cavity and pleura, heart, lung, trachea, thymus, cerebrum*, middle ear and application site.
Parameters marked with * only examined in cases of suspected pathology due to the intoxication or other special pathological-anatomical findings. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 other: g/kg
- Based on:
- test mat.
- Mortality:
- All ten animals survived the testing period.
- Clinical signs:
- other: In five animals (4 males/1 female) slight swelling of the spleen was observed. Five animals (1 male/4 females) appeared to be unaffected.
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- Under the conditions of the study, the LD50 was determined to be > 4.0 g/kg in male and female rats.
- Executive summary:
The potential of the test material to cause acute oral toxicity in the rat was investigated in accordance with sound scientific principles. The test material was administered to 5 male and 5 female rats as a limit dose in an emulsion, using a vehicle of carboxymethylcellulose (0.5 g CMC in 100 mL distilled water). The rats were treated with 4 g/kg of the test material.
Animals were observed for mortality and abnormal clinical signs for a period of 12 days after administration. All animals were weighed prior to treatment. All ten animals survived the test and were sacrificed at the end of the 12 day observation period.
In five animals (4 males/1 female), slight swelling of the spleen was observed whilst five animals (1 male/4 females) appeared to be unaffected.
Under the conditions of the study, the LD50 was determined to be > 4.0 g/kg in male and female rats.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study does not specify any particular guidelines but was conducted to sound scientific principles. The study report is in German.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The methodology used was similar to that outlined in OECD Guideline 401 (Acute Oral Toxicity). Fasted rats were dosed once with the test material by gavage.
- GLP compliance:
- no
- Remarks:
- Study conducted in 1970, prior to introduction of GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 110 to 140 g
- Fasted before study: Yes (no data on fasting period)
- Housing: The animals were kept in containers in pairs
- Diet: ad libitum
- Water: ad libitum - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 40.0 mL/kg
DOSAGE PREPARATION: The test material was administered undiluted - Doses:
- 4.8, 5.76, 6.91, 10.0, 12.0, 14.4, 17.3, 24.9, 29.9, 36.0 and 40.0 mL/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Daily
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs were monitored and gross pathological findings recorded - Statistics:
- The LD50 and confidence limits were calculated using Probit analysis.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 27.54 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 23.89 - 31.77
- Mortality:
- At the highest dose of 40.0 mL/kg, all five rats died within the 14 day observation period. At 36.0 mL/kg, four out of the five rats which received this dose died. Three rats dosed at 29.9 mL/kg died, as did two rats that received a dose at 24.9 mL/kg. No further mortalities occurred with animals that were dosed at 17.3 mL/kg or lower.
- Clinical signs:
- other: Animals dosed at 14.4 mL/kg and higher were observed to demonstrate the usual, uncharacteristic poisoning symptoms of organo-tin compounds. Immobility, weariness and lack of interest in food were also observed. Rats dosed at 24.9 mL/kg rat and above were
- Gross pathology:
- The sections offered no abnormal findings.
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- Under the conditions of the study, the LD50 was determined to be 27.54 mL/kg (28 641.6 mg/kg) with 95 % CL of 23.89 to 31.77 mL/kg in male rats.
- Executive summary:
The potential of the test material to cause acute oral toxicity in the rat was investigated in a study that was performed using methodology similar to that outlined in the standardised guideline OECD 401.
This study was performed with Wistar male rats. The animals (5/dose level) received a single dose of the undiluted test material via gavage. The dose levels were as follows: 4.8, 5.76, 6.91, 10.0, 12.0, 14.4, 17.3, 24.9, 29.9, 36.0 and 40.0 mL/kg. The animals were observed for 14 days and sacrificed after this period.
Mortalities were observed at the dose of 24.9 mL/kg and above. Animals dosed at 14.4 mL/kg and higher were observed to demonstrate the usual, uncharacteristic poisoning symptoms of organo-tin compounds. Immobility, weariness and lack of interest in food were also observed.
Rats dosed at 24.9 mL/kg and above were reported after 2 to 6 day to show signs of respiratory and circulatory paralysis and mortality. The animals that survived recovered after 4 to 6 days. With regards to gross pathology, the sections offered no abnormal findings.Under the conditions of the study, the LD50 was determined to be 27.54 mL/kg (28 641.6 mg/kg) with 95 % CL of 23.89 to 31.77 mL/kg in male rats.
Referenceopen allclose all
Table 1: Dose Levels, Number of Test Animals and Percentage Mortality
Undiluted dose of test material (mL/kg) |
Number of rats per dose |
Number of mortalities |
Percentage mortality (%) |
40.0 |
5 |
5 |
100 |
36.0 |
5 |
4 |
80 |
29.9 |
5 |
3 |
60 |
24.9 |
5 |
2 |
40 |
17.3 |
5 |
0 |
0 |
14.4 |
5 |
0 |
0 |
12.0 |
5 |
0 |
0 |
10.0 |
5 |
0 |
0 |
6.91 |
5 |
0 |
0 |
5.76 |
5 |
0 |
0 |
4.80 |
5 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 000 mg/kg bw
- Quality of whole database:
- Two key studies are available and both were awarded a reliability score of 2 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997). The studies were conducted prior to GLP and do not specify any particular guidelines; however, both studies were conducted to sound scientific principles. The quality of the database is therefore considered to be adequate.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male and female rats were exposed to the test material as an aerosol mist for 4 hours.
- GLP compliance:
- no
- Remarks:
- Study conducted in 1974, prior to inception of GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: 54 Tif. RAI (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bred in-house at the testing facility
- Age at study initiation: 7 to 8 weeks old
- Weight at study initiation: 175 to 185 g (male and female)
- Housing: The male and female rats were segregated (9 animals to a cage) during observation period
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 1 °C
- Humidity: Approximately 50 % (relative) - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: The exposure system used in the test was that described by Sachsse et al., 1974 (Sachsse K, Ullmann L, Voss G & Hess R: Measurement of inhalation toxicity of aerosols in small laboratory animals. Proceedings of the European Society for the study of Drug Toxicity Volume XV, 239, 1974). The animals were not exposed until the aerosol was evenly dispersed throughout the chamber (15 minutes).
- Method of holding animals in test chamber: The test animals were kept in separate PVC tubes positioned radially around the exposure chamber.
- Source and rate of air: The test material was sprayed into the exposure chamber by means of a pressure nozzle. The liquid was injected by a motor-driven syringe at a rate of 0.9, 3 and 12 mL/hr into a stream of compressed air (2 atm.) flowing through a spray nozzle at a rate of 10 L/min. The aerosol mist thus produced was discharged into the exposure chamber.
- Method of particle size determination: Gravimetrically
TEST ATMOSPHERE
- Brief description of analytical method used: The particle-size distribution in the aerosol was determined gravimetrically on Selectron-Filters, pore size 0.2 µm every hour with the aid of a Cascade Impactor (C.T. Casella and Co., Ltd).
- Samples taken from breathing zone: Yes. The aerosol in the immediate vicinity of the animals was sampled on membrane filters, pore size 0.2 µm (Satorius) hourly after the beginning of the test.
VEHICLE
- Concentration of test material in vehicle: 92, 224 and 718 mg/m³
TEST ATMOSPHERE
- At 92 mg/m³ the mean particle size distribution was 44, 19, 21 and 16 % of the particles >7, 3 to 7, 1 to 3 and <1 µm, respectively.
- At 224 mg/m³ the mean particle size distribution was 59, 16, 20 and 5 % of the particles >7, 3 to 7, 1 to 3 and <1 µm, respectively.
- At 718 mg/m³ the mean particle size distribution was 55, 14, 24 and 7 % of the particles >7, 3 to 7, 1 to 3 and <1 µm, respectively. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 92, 224 and 718 mg/m²
- No. of animals per sex per dose:
- 9 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Clinical signs were recorded throughout the 7 day observation period.
- Necropsy of survivors performed: Yes - Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 250 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- All of the 18 rats (9 male and 9 female) that were exposed to the lowest concentration of test material, 92 mg/m³, survived.
Three male and three female rats died between 24 and 48 hours after being exposed to the median test material concentration of 224 mg/m³. A further male rat died prior to the end of the 7 day observation period.
At the highest concentration of test material, 718 mg/m³, all 9 male and all 9 female rats had died within 24 hours of exposure. - Clinical signs:
- other: After the 4-hour exposure the rats in concentrations where mortalities occurred (224 mg/m³ and 718 mg/m³) showed signs of dyspnoea, lateral position, cyanosis, apathy and ruffled fur. These symptoms became more accentuated as test material concentration i
- Gross pathology:
- Haemorrhages in the lungs and congested organs were observed in the animals that died during the study. In those that were sacrificed after the 7 day observation period, no test material related gross organ changes were seen.
- Interpretation of results:
- other: Category 2 in accordance with EU criteria
- Conclusions:
- Under the conditions of the study, the LC50 of the test material was found to be 250 mg/m³ (0.25 mg/L) in male and female rats.
- Executive summary:
The acute inhalation toxicity of the test material was investigated in a study which was conducted in accordance with generally accepted scientific principles.
During the study, the test material was administered to three separate groups of albino rats, each group comprised of 9 males and 9 females. The rats were exposed to the test material for a period of 4 hours, via nose-only exposure, as an aerosol mist at concentrations of 92, 224 and 718 mg/m³. The individual concentrations of the test material were gravimetrically determined.
The exposure system used in the study was that described by Sachsse et al. (1974); the test material was sprayed into the exposure chamber by means of a pressure nozzle. The liquid was injected by a motor-driven syringe at a rate of 0.9, 3 and 12 mL/hr into a stream of compressed air (2 atm.) flowing through a spray nozzle at a rate of 10 L/min. The aerosol mist thus produced was discharged into the exposure chamber.
All of the 18 rats (9 male and 9 female) that were exposed to the lowest concentration of test material, 92 mg/m³, survived. Three male and three female rats died between 24 and 48 hours after being exposed to the median test material concentration of 224 mg/m³. A further male rat died prior to the end of the 7 day observation period. At the highest concentration of test material, 718 mg/m³, all 9 male and all 9 female rats had died within 24 hours of exposure.
The rats in concentrations where mortalities occurred (224 mg/m³ and 718 mg/m³) showed signs of dyspnoea, lateral position, cyanosis, apathy and ruffled fur. These symptoms became more accentuated as test material concentration increased. The surviving animals had recovered within 4 to 5 days.
Haemorrhages in the lungs and congested organs were observed in the animals that died during the study. In those that were sacrificed after the 7 day observation period, no test material related gross organ changes were seen.
Under the conditions of the study, the LC50 of the test material was found to be 250 mg/m³ (0.25 mg/L) in male and female rats.
Reference
Table 1: Mortality Results
Concentration (mg/m³) |
Exposure time (hours) |
No. of Animals |
Died within |
||||||||
0 - 4 hours |
24 hours |
48 hours |
7 days |
||||||||
|
|
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
92 |
4 |
9 |
9 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
224 |
4 |
9 |
9 |
0 |
0 |
0 |
0 |
3 |
3 |
4 |
3 |
718 |
4 |
9 |
9 |
0 |
0 |
9 |
9 |
9 |
9 |
9 |
9 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 250 mg/m³ air
- Quality of whole database:
- Study conducted in 1974, prior to introduction of GLP. Study does not specify any particular guidelines but was conducted to sound scientific principles; possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results. The study was assigned a reliability score of 2 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997). The quality of the database is therefore considered to be good.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Oral Toxicity
There are two studies provided to address this endpoint; both were considered to be key as both were awarded the same reliability score of 2 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997). Both studies were performed in accordance with sound scientific principles prior to the inception of GLP.
In the first key study (Günzel & Richter, 1968), the potential of the test material to cause acute oral toxicity in the rat was investigated in accordance with sound scientific principles.
The test material was administered to 5 male and 5 female rats as a limit dose in an emulsion, using a vehicle of carboxymethylcellulose (0.5 g CMC in 100 mL distilled water). The rats were treated with 4 g/kg of the test material.
Animals were observed for mortality and abnormal clinical signs for a period of 12 days after administration. All animals were weighed prior to treatment. All ten animals survived the test and were sacrificed at the end of the 12 day observation period.
In five animals (4 males/1 female), slight swelling of the spleen was observed whilst five animals (1 male/4 females) appeared to be unaffected.
Under the conditions of the study, the LD50 was determined to be > 4.0 g/kg in male and female rats.
In the second key study (Klimmer, 1970), the potential of the test material to cause acute oral toxicity in the rat was investigated in a study that was performed using methodology similar to that outlined in the standardised guideline OECD 401.
This study was performed with Wistar male rats. The animals (5/dose level) received a single dose of the undiluted test material via gavage. The dose levels were as follows: 4.8, 5.76, 6.91, 10.0, 12.0, 14.4, 17.3, 24.9, 29.9, 36.0 and 40.0 mL/kg. The animals were observed for 14 days and sacrificed after this period.
Mortalities were observed at the dose of 24.9 mL/kg and above. Animals dosed at 14.4 mL/kg and higher were observed to demonstrate the usual, uncharacteristic poisoning symptoms of organo-tin compounds. Immobility, weariness and lack of interest in food were also observed.
Rats dosed at 24.9 mL/kg and above were reported after 2 to 6 day to show signs of respiratory and circulatory paralysis and mortality. The animals that survived recovered after 4 to 6 days. With regards to gross pathology, the sections offered no abnormal findings.Under the conditions of the study, the LD50 was determined to be 27.54 mL/kg (28 641.6 mg/kg) with 95 % CL of 23.89 to 31.77 mL/kg in male rats.
Acute Inhalation Toxicity
The acute inhalation toxicity of the test material was investigated in a study which was conducted in accordance with generally accepted scientific principles.
During the study, the test material was administered to three separate groups of albino rats, each group comprised of 9 males and 9 females. The rats were exposed to the test material for a period of 4 hours, via nose-only exposure, as an aerosol mist at concentrations of 92, 224 and 718 mg/m³. The individual concentrations of the test material were gravimetrically determined.
The exposure system used in the study was that described by Sachsse et al. (1974); the test material was sprayed into the exposure chamber by means of a pressure nozzle. The liquid was injected by a motor-driven syringe at a rate of 0.9, 3 and 12 mL/hr into a stream of compressed air (2 atm.) flowing through a spray nozzle at a rate of 10 L/min. The aerosol mist thus produced was discharged into the exposure chamber.
All of the 18 rats (9 male and 9 female) that were exposed to the lowest concentration of test material, 92 mg/m³, survived. Three male and three female rats died between 24 and 48 hours after being exposed to the median test material concentration of 224 mg/m³. A further male rat died prior to the end of the 7 day observation period. At the highest concentration of test material, 718 mg/m³, all 9 male and all 9 female rats had died within 24 hours of exposure.
The rats in concentrations where mortalities occurred (224 mg/m³ and 718 mg/m³) showed signs of dyspnoea, lateral position, cyanosis, apathy and ruffled fur. These symptoms became more accentuated as test material concentration increased. The surviving animals had recovered within 4 to 5 days.
Haemorrhages in the lungs and congested organs were observed in the animals that died during the study. In those that were sacrificed after the 7 day observation period, no test material related gross organ changes were seen.
Under the conditions of the study, the LC50 of the test material was found to be 250 mg/m³ (0.25 mg/L) in male and female rats.
Acute Toxicity: Other Routes
The potential of the test material to cause acute toxicity via the intraperitoneal route in the rat was investigated in accordance with sound scientific principles. The study was assigned a reliability score of 2 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997).
The test material was administered as an emulsion using a vehicle of carboxymethylcellulose (0.5 g CMC in 100 mL distilled water) to male and female Sprague Dawley rats. The test material was administered at dose levels of 90, 180, 250, 360, 500 and 720 mg/kg to 5 animals per sex per dose.
Mortality and abnormal clinical signs were recorded initially after administration of the test material and once daily, for a period of 7 days thereafter. All animals were weighed prior to treatment. A necroscopy was performed for all the animals that died during the study and for the surviving rats on completion of the test.
No mortality and clinical signs were observed at the lower dose levels of 90 mg/kg and 180mg/kg.
In the 250 mg/kg dose group, 1 female animal died 3 days after test material administration. In the 360 mg/kg dose group, 3 female animals died 1 day after application; the remaining two females and two males died on day 2 after test material administration. In the 500 mg/kg dose group, 4 males and 5 females died 1 day after dosing, with the remaining male animal dying on day 2. In the 720 mg/kg dose group, all animals died 1 day after test material administration. The only clinical sign recorded for animals in these dose groups was apathy.
Observations recorded at necropsy for animals dying during the study and those sacrificed at the end of the observation period included hydrops ascites, test material remained in abdomen, haemorrhagic erosion in stomach, intestines were stuck together and hydrothorax. A further sign observed in the sacrificed animals was swollen liver.
Under the conditions of the study, the LC50 was determined to be 325 mg/kg with 95 % CL of 271 to 390 mg/kg in male and female rats.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008, the substance does not require classification with respect to acute toxicity via the oral route.
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008, the substance requires classification with respect to acute toxicity via inhalation as Category 2 (H330: Fatal if inhaled).
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