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EC number: 237-748-4 | CAS number: 13967-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, follows standard guidelines. Available as an unpublished report, acceptable without restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium dicyanoaurate
- EC Number:
- 237-748-4
- EC Name:
- Potassium dicyanoaurate
- Cas Number:
- 13967-50-5
- Molecular formula:
- C2AuN2.K
- IUPAC Name:
- potassium dicyanoaurate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Potassium dicyanoaurate
- Molecular formula (if other than submission substance): KAu(CN)2
- Substance type: White powder
- Physical state: Solid
- Stability under test conditions: stable under standard conditions.
- Storage condition of test material: At room temperature.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD / Crl: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Research Models and Services, Sulzfeld, Germany
- Age at study initiation: approx. 8 weeks
- Weight at study initiation: 258 - 268 g (males), 222 - 252 g (females)
- Fasting period before study: Yes, feeding discontinued approx. 16 hours before administration of test item.
- Housing: During the 14-day observation period the animals were kept singly in MAKROLON cages (type III plus) with granulated textured wood (Granulat A2, J. Brandenburg, Germany) as bedding material.
- Diet (e.g. ad libitum): Commercial diet, ssniff® R/M-H V1534 (ssniff Spezialdiäten GmbH, 59494 Soest, Germany) ad libitum with exception of 16 h fasting period before administration of test item.
- Water (e.g. ad libitum): ad libitum
- Acclimation period: At least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 3°C
- Humidity (%): 55% ± 15%
- Photoperiod (hrs dark / hrs light): 12 h dark / 12 h light (about 150 lux at approx. 1.5 m room height)
IN-LIFE DATES: From: 17 July 2014 To: 24 July 2014
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Remarks:
- Aqua ad iniectabilia
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5 x 6 cm
- % coverage: 10 %
- Type of wrap if used: 8 layers gauze covered with a plastic sheet and secured with adhesive plaster.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No, residues of test item were not removed.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.7255 mL/kg b.w. preparation based on volume. 10 g Potassium dicyanoaurate mixed with 5 g water resulting in suspension with the density of 1.7386 g/mL.
- Concentration (if solution): 2000 mg/kg b.w.
- Constant volume or concentration used: no
- For solids, paste formed: no, suspension with a density of 1.7386 g/mL was used. - Duration of exposure:
- Exposure time was 24 hours.
- Doses:
- One dose level of 2000 mg/kg b.w. was examined.
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: before and immediately, and 5, 15, 30, 60 min, as well as 3, 6, and 24 hours after application of test item.
- Necropsy of survivors performed: yes
- Other examinations performed: changes of skin and fur, eyes and mucous membranes, respiratory and circulatory function, autonomic and central nervous system and somatomotor activity as well as behaviour pattern, were observed at least once a day until all symptoms subsided, thereafter each working day. Attention was also paid to possible tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma. Observations on mortality were made at least once daily. Individual body weights were recorded before administration of the test item and thereafter in weekly intervals up to the end of the study. Changes in weight were calculated and recorded. The skin was observed for the development of erythema and oedema. At the end of the experiments, all animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities observed during the test.
- Clinical signs:
- other: No clinical signs observed.
- Gross pathology:
- No macroscopic findings observed at necropsy.
Any other information on results incl. tables
Table 1. Summary of effects
Symptoms/Criteria |
Potassium dicyanoaurate 2000 mg/kg b.w. (n=5) |
|
|
males |
females |
Clinical signs |
None |
None |
Skin reactions |
None |
None |
Mortality 6 h |
0 |
0 |
24 h |
0 |
0 |
7 d |
0 |
0 |
14 d |
0 |
0 |
Mean body weight gain (g) Start |
264.6 |
237.2 |
After 7 d |
297.6 (+12.5) |
238.8 (+0.7) |
After 14 d |
351.6 (+32.9) |
256.8 (+8.3) |
Inhibition of bodyweight gain |
None |
None |
Necropsy findings |
None |
None |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the EC-Commission directive 67/548/EEC and its subsequent amendments Potassium dicyanoaurate requires no labelling.
The test material is not classified for acute dermal toxicity according to the EC Regulation 1272/2008 and subsequent regulations and according to the Globally Harmonized Classification System (GHS). - Executive summary:
Acute dermal toxicity study of Potassium dicyanoaurate was according to OECD guideline 402 and EC method B.3 in rats. The test was conducted according to GLP.
The test item Potassium dicyanoaurate was applied dermally, on the shaved intact dorsal skin to rats once for 24 hours. This treatment was followed by an observation period of 2 weeks.
Under the test conditions, a single dermal administration of 2000 mg Potassium dicyanoaurate/kg b.w. did not reveal any signs of toxicity. No animal died prematurely. All animals gained the expected weight throughout the whole experimental period. The LD50 was determined to be >2000 mg/kg b.w. According to the EC-Commission directive 67/548/EEC and its subsequent amendments Potassium dicyanoaurate requires no labelling. The test material is not classified for acute dermal toxicity according to the EC Regulation 1272/2008 and subsequent regulations and according to the Globally Harmonized Classification System (GHS).
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