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EC number: 918-906-8 | CAS number: 65684-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Data investigating the aquatic toxicity of Glyceryl undecylenate
(CAS 123759-97-7) are not available.
In accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006,
read-across from structurally related substances Glyderides, C14-18 and
C16-18 unsatd. mono-, di- and tri- (CAS 91052-28-7) and Glycerides,
C8-10, mono- and di- (CAS 85536-07-8) was conducted to fulfil the
standard information requirements. In accordance with Article 13 (1) of
Regulation (EC) No 1907/2006, "information on intrinsic properties of
substances may be generated by means other than tests, provided that the
conditions set out in Annex XI are met.” In particular for aquatic
toxicity, information shall be generated whenever possible by means
other than vertebrate animal tests, which includes the use of
information from structurally related substances (grouping or
read-across). According to Annex XI, Item 1.5, of Regulation (EC) No
1907/2006 substances can be considered similar if their physicochemical,
toxicological and ecotoxicological properties are likely to be similar
or follow a regular pattern as a result of structural similarity.
The target and the source substances are esters of a tri-functional alcohol (glycerol) with one or more carboxylic (fatty) acid(s) chain(s). The alcohol moiety (glycerol) is common to all analogue substances. The fatty acid moiety comprises carbon chain lengths from C8-C18 and includes mainly linear saturated alkyl chains, but also unsaturated chains bound to the alcohol, resulting in mono-, di-, and tri-esters. The target substance and the source substance Glyderides, C14-18 and C16-18 unsatd. mono-, di- and tri- (CAS 91052-28-7) are characterised by a low water solubility (<1 mg/L). The water solubility of the second source substance Glycerides, C8-10, mono- and di- (CAS 85536-07-8) is higher compared to the target substance (46 mg/L at 20 °C). The read across is therefore considered as a worst case approach. The available short-term and long-term studies indicate that the source substances are not acutely or chronically toxic to aquatic organisms up to the limit of water solubility of the source substances.
In the acute toxicity studies conducted with the source substance Glyderides, C14-18 and C16-18 unsatd. mono-, di- and tri- (CAS 91052-28-7) EL/LL50 values >100 mg/L were determined for fish, aquatic invertebrates and algae. The reported LL/EL50 values for the second source substance Glycerides, C8-10, mono- and di- (CAS 85536-07-8) for fish, aquatic invertebrates and algae were 75, 218.2 and 49 mg/L, respectively. The determinded NOEC for algae was 20.7 mg/L. In this test, the algae were reported to be encased by small dispersed particles in the suspension (confirmed by microscopical observation). Therefore, a physical interference of test substance particles with algae cells may also have contributed to the observed effect. The Guidance on information requirements and chemical safety assessment, Chapter R.7b, states that poorly water-soluble substances often have technical difficulties during aquatic testing, therefore one should treat results from tests above the limit of solubility with care and they “should not be interpreted as pelagic toxicity, but as confounded by physical effects” (ECHA, 2014). This also may have been the case in the two experimental studies on the source substance Glycerides, C8-10 mono- and di (CAS 85536-07-8) conducted with fish and aquatic invertebrates. Due to the readily biodegradable nature of the substance, such high concentrations are no expected to be reached in natural waters. Therefore, in accordance with the 5th ATP of Regulation (EC) No. 1272/2008, the substance was not classified as dangerous for the environment. The assumption is supported by a study on phase behaviour of lipid/surfactant/water phases demonstrating the technical difficulties for aquatic toxicity testing of this type of Glycerides (Prajapati et al., 2012; see IUCLID section 6.1.4).
The assessment of the toxicity to microorganisms is based on the toxicity control of the biodegradation test performed with the source substance Glycerides, C8-10 mono- and di (CAS 85536-07-8). The ready biodegradability study was conducted according to OECD 301B including a toxicity control with 46.9 mg/L test material (Flach, 2012). A degradation rate of 81.1% within 14 days was determined in the toxicity control clearly indicating the lack of toxic potential of Glycerides, C8-C10, mono- and di- to activated sludge microorganisms. Therefore, the test item concentration of 46.9 mg/L allows to derive the NOEC as ≥ 46.9 mg/L.
Based on the result from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that Glyceryl undecylenate (CAS 123759-97-7) is not acutely or chronically toxic to freshwater organisms up to the limit of the water solubility (WS < 1 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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