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EC number: 436-230-7 | CAS number: 359406-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 0.179 mg/L (based on the solid content of the test item).
NOEC = 0.28 mg/L (based on the Proban STi included water).
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 0.179 mg/L
Additional information
No study on the activated sludge inhibition is available for the substance. However, a study performed according to OECD 303A is available (Stewart, 2007 reported in the section 5.2.2 of IUCLID 5 : Biodegradation in water and sediment: simulation tests). No toxicity to the micro organism population has been observed in this test. Therefore, the concentration used for the test (i.e. 0,179 mg/L) can be considered as a NOEC.
To assess the suitability of this NOEC value, results obtained on two analogue substances are used as a read across approach (see "read across justification" in the section 4 and 5 for explanation). Three experimental studies performed according to OECD Guideline n° 209 are available and the results obtained are described below.
Two studies were carried out with Proban CC, a structural analogue of the Perform STi. In the first study (Handley, 1992), the EC50 3h was 74 mg/L and in the second study (Mead, 1994), the EC50 3h was 190 mg/L. No NOEC values are reported in these studies, but based on the respiration inhibition observed, NOEC values of 5,6 mg/L and 100 mg/L can respectively be considered.
The third study (Croudace, 1995) was carried out with ITC 826, another structural analogue of the Perform STi. The NOEC 3h reported in this study was 10 mg/L.
The NOEC values obtained in activated sludge respiration inhibition studies performed on two structural analogue substances are at least 300 times higher than the NOEC of the substance deduced from an OECD Guideline 303A study. Therefore, it can be considered that this NOEC can be used as a worst case value for the derivation of the PNEC for STP. Additionnally, this NOEC value is considered as sufficiently protective to apply an assessment factor equal to 1 to derive the PNEC in accordance with the ECHA guidance R10. This approach gives a PNECSTP of 0,179 mg/L.
For comparaison, the PNECSTP determined for the two structural analogue substances, considering the above toxicity results, are the following:
- Proban CC: PNECSTP = 0,74 mg/L and 1,9 mg/L (based on EC50 value)
- Proban CC : PNECSTP= 0,56 mg/L and 10 mg/L (based on NOEC value)
- ITC 826: PNECSTP = 1 mg/L
Conclusion
The PNECSTP value determined for the three structural analogue substances are in same order of magnitude or above, with the value of 0,179 mg/L being the lowest one. Therefore, the PNECSTP of 0,179 mg/L is considered as a relevant worst case value for the substance.
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