Aluminium nitride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The acute inhalation toxicity study of Landry (1994) was cited in the GLP 28 day repeated dose toxicity study (see section 7.5.2). This acute inhalation toxicity study was as a pre-test for the 28 day repeated dose toxicity study and was conducted in the same laboratory Toxicology Research Laboratory) and with the same study authors as the 28 day repeated dose toxicity study. Therefore, the results are considered reliable even though the study is not reported in detail.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1994

Report date:

1994

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1994

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not specified

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Aluminium nitride

EC Number:

246-140-8

EC Name:

Aluminium nitride

Cas Number:

24304-00-5

Molecular formula:

AlN

IUPAC Name:

alumanylidyneamine

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): Aluminum nitride

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

not specified

Details on test animals or test system and environmental conditions:

no further information available

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

no further information available

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

317 mg/m³

No. of animals per sex per dose:

no data available

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Statistics:

N.A.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 317 mg/m³ air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: no remarkable effects were observed

Mortality:

no mortality occured

Clinical signs:

other: no detailed information provided but it was mentioned that no remarkable effects were observed

Body weight:

no detailed information provided but it was mentioned that no remarkable effects were observed

Gross pathology:

no detailed information provided but it was mentioned that no remarkable effects were observed

Any other information on results incl. tables

Aerodynamic Diameter: the mass median aerodynamic diameter was 1.7 µm, with 84% of the particles less than 3.0 µm

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In conclusion, in an acute inhalation toxicity study rats were exposed to 317 mg/m³ for four hours to aluminum nitride. No remarkable adverse effects were noted. Thus, based on the results presented the LC0 can be considered to be greater than 317 mg/m³.

Executive summary:

In an acute inhalation toxicity study rats were exposed to 317 mg/m³ of aluminium nitride for four hours. After treatment the animals were observed for two weeks. The mass median aerodynamic diameter was 1.7 µm, with 84% of the mass in particles less than 3.0 µm. No mortality occurred and no remarkable adverse effects were noted. Thus, based on the results presented the LC0 can be considered to be greater than 317 mg/m³.