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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1969
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: experimental details lacking; however, followed accepted methodology at time of testing
Qualifier:
no guideline available
Principles of method if other than guideline:
The test has been conducted prior to the current OECD guideline however, the LD50 calculation was based on an accepted method (Miller and Tainter).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
The animals were fasted 12 hours prior to dosing.
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Oral intubation
Doses:
100, 316, 1000, 3160, 5000 and 10000 mg/Kg
No. of animals per sex per dose:
6 groups of 6 animals (1 dose/animal)
Control animals:
no
Sex:
male
Dose descriptor:
LD50
Effect level:
> 7 000
Based on:
test mat.
Remarks on result:
other: as calculated by method of Miller and Tainter
Other findings:
principle toxic effect: Sedation
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on this test the LD50 was determined to be 7000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
7 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of acute toxicity – oral endpoint
The results obtained experimentally for acute oral toxicity were acquired prior to the establishment of accepted guidelines or Good Laboratory Practices (GLPs); however, the LD50 calculation was based on an accepted method (Miller and Tainter). The prediction obtained from OECD [Q]SAR Toolbox (v 3.3) supports the calculation from the experimentally derived data. Thus, it is acceptable to use the experimental LD50 value of 7000 mg/kg for the purposes of classification.

Justification for classification or non-classification

No classication needed as the experimentally-derived LD50 of 7000 mg/kg is supported by the OECD Toolbox prediction.