Registration Dossier
Registration Dossier
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EC number: 203-254-2 | CAS number: 104-94-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity study was conducted on rats
- GLP compliance:
- no
- Test type:
- other: Not reported
Test material
- Reference substance name:
- p-anisidine
- EC Number:
- 203-254-2
- EC Name:
- p-anisidine
- Cas Number:
- 104-94-9
- Molecular formula:
- C7H9NO
- IUPAC Name:
- 4-methoxyaniline
- Details on test material:
- - Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not reported
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- Not reported
- Doses:
- Not reported
- No. of animals per sex per dose:
- Not reported
- Control animals:
- not specified
- Details on study design:
- Not reported
- Statistics:
- Not reported
Results and discussion
- Preliminary study:
- Not reported
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The observed effects were hematologic changes , anemia and nephrotoxicity
- Mortality:
- Not reported
- Clinical signs:
- Not reported
- Body weight:
- Not reported
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 in rats after oral exposure to 4 methoxyaniline in 1400mg/kgw
- Executive summary:
Acute Oral toxicity study was conducted on rats.
The rats were orally dosed with the test chemical and effects were observed
The observed effects were hematologic changes , anemia and nephrotoxicity
The acute oral LD50 in rats after oral exposure to 4 methoxyaniline in 1400mg/kgw
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