Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 282-775-7 | CAS number: 84418-63-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EL10 (6 h) > 50 mg/L (ISO 10712, Pseudomonas putida), read across
NOEC (14 d) > 28.7 mg/L (OECD 301 B, Toxicity Control), read across
Key value for chemical safety assessment
Additional information
Since no experimental studies investigating the toxicity of 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3, UVCB) towards aquatic microorganisms are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance 3,5,5-trimethylhexanoic acid hexaester with dipentaerythritol (CAS 84418-63-3, mono) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID section 13. Both substances consist of the same alcohol component (dipentaerythritol) and an equal fatty acid chain length (C9iso, respectively) but with different degrees of esterifications.
One study investigating the toxicity of 3,5,5-trimethylhexanoic acid hexaester with dipentaerythritol (CAS 84418-63-3) to aquatic microorganisms is available. The GLP study was conducted similarly to ISO 10712 investigating the inhibition of growth of Pseudomonas putida (Comber, 1993). A Water Accommodated Fraction (WAF) of nominal 50 mg/L was used for the test. No inhibitory effect was observed after 6 h. Hence the EL10 was determined to be > 50 mg/L (nominal) based on growth inhibition.
Additionally a ready biodegradability study for this substance was used to derive a NOEC for the toxicity to aquatic microorganisms. In accordance with the ECHA Guidance R.7b (ECHA, 2014) the result from a biodegradation study can be used to derive a NOEC if a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration (biodegradation > 25%). The toxicity control in this OECD 301B test, containing 28.7 mg/L of the test item and 26 mg/L of the reference material aniline attained 41.5% degradation after 14 days of incubation. Thus, a NOEC of ≥ 28.7 mg/L was derived for 3,5,5-trimethylhexanoic acid hexaester with dipentaerythritol (CAS 84418-63-3).
Based on the available results from this structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3) will not exhibit adverse effects to aquatic microorganisms even at concentrations well above the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.