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EC number: 265-334-3 | CAS number: 65059-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- None
- GLP compliance:
- yes
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- Not available
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:
The test medium used had the following composition :
stock solution concentration in test
NaHC03 65 mg/1 MgS0 4 : 65 mg/1
MgS0 4 * 7 H 2 0 123.3 mg/1
KCI 5.8 mg/1
CaCI 2 * 2 H20 294 mg/1
Na 2 Si03 *9H2O 10 mg/1
NaN03 274 ug/L
KH 2 PO4 143 ug/L
K 2 HP0 4 184 ug/L
The test water medium was prepared with bidistilled water
The pH was in a range of 7.8- 8.2
Test No. : G 171 14
The medium was oxygen saturated at the beginning of the test. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Method of breeding: Cultures of Daphnia magna are maintained in glass vessels containing aprox. 3.0 L of reconstituted water (see test medium) at 18 - 22 °C. The water was renewed partially three times weekly. The daphnids were feed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantities that the food was consumed within 24h.
- Pretreatment: 24 hours before the start of the exposure reproductive daphnids were separated from the young daphnids by sieving all individuals through a 710 µm sieve.
The quality of the daphnids is checked at least every 3 months by determining the EC50 values (24 h) for potassium dichromate (range: 0.8- 1.5 mg/l). For each concentration, of test substance, 20 daphnids divided in two groups of 10 animals are used. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Test evaluations were done according to the guidelines by visual assessment of mobility of the daphnids after 24 and 48 hours.
- Hardness:
- 136 mg/L CaC03
- Test temperature:
- 21 °C
- pH:
- 7.8- 8.2
- Dissolved oxygen:
- Not available
- Salinity:
- 0.8 mmol/L
- Nominal and measured concentrations:
- Based on a pretest, the test concentrations were chosen as 58/100 and 180 mg/L nominal.
- Details on test conditions:
- - Ca/mg ratio: 4 : 1
- Alkalinity: 0.8 mmol/L - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- In the control and in all test concentrations no immobilization of the Daphnia was observed.
- Results with reference substance (positive control):
- Potassium dichromate ( EC50: 1.01 mg/L )
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 and EC100 values are clearly higher than 8 mg/L after 48 hours. The EC50 values could not be calculated.
- Executive summary:
Short-term toxicity of FAT 36152/G to Daphnia magna was determined in a 48-hours static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 841449, L 251, Part C 2. The test was performed in compliance with the Good Laboratory Practice Regulations. The nominal concentrations tested were 58/100 and 180 mg/L, and a control without any additions. The test concentrations were prepared from the supernatant of a 0.5 g/0.5 l stock solution, in which most of the substance was settled down. For the preparation of the test concentrations only the supernatant of the stock solution was taken. The reported results are related to the analytical concentrations of the test article. During test duration the test article concentrations in the analysed test media were in the range of <3.4 - 15.0 % of the nominal values. In the control and in all test concentrations no immobilization of the Daphnia was observed. The EC0 value is at least 8 mg/l, but might even be higher than this concentration, the EC50 and EC100 values are clearly higher than 8 mg/l after 48 hours. Therefore, the EC50 values could not be calculated.
Results: (24h & 48h)
EC0: >8 mg/l
EC50: >8 mg/l
EC100:>8 mg/l
NOEC: ≥8 mg/l
Reference
Immobilization of daphnids:
Nominal Conc. Of test material (mg/l) | No. of animals | no. of responses | % immobility | ||
24 h | 48 h | 24 h | 48 h | ||
Blank | 10 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
58 | 10 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
100 | 10 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | |
180 | 10 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 |
Description of key information
The EC50 and EC100 values are higher than 8 mg/l after 48 hours.
Key value for chemical safety assessment
Additional information
Short-term toxicity of FAT 36152/G to Daphnia magna was determined in a 48-hours static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 841449, L 251, Part C 2. The nominal concentrations tested were 58/100 and 180 mg/L. During test duration the test article concentrations in the analysed test media were in the range of <3.4 - 15.0 % of the nominal values, hence the results were reported in terms of measured concentrations. In the control and in all test concentrations no immobilization of the Daphnia was observed. Therefore, the EC0, EC50 and EC100 values for 48-hours exposure duration were considered to be >8 mg/l
In another supporting study, short-term toxicity of FAT 36152/D to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adopted 4 April 84. The nominal concentrations tested were 0.04, 0.20, 0.40, 2.0 and 4.0 mg test substance/L, a solvent control group and a control without any additions. In the control no immobility or mortality of the test animals was observed. FAT 36152/D had no acute toxic effect on Daphnia magna during the test duration of 48 hours up to the highest concentration tested of 4.0 mg test substance/l (as the highest concentration that was possible to dissolve in dimethylformamid p.A. at room temperature and an addition of 100 µL solvent stock solution to 1 L test medium). Therefore, the NOEC (highest concentrationtested without toxic effect) of FAT 36152/D was determined to be 4.0 mg/L or higher.
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