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Diss Factsheets
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EC number: 204-593-9 | CAS number: 123-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Cetylpyridium Chloride
- IUPAC Name:
- Cetylpyridium Chloride
- Reference substance name:
- Cetylpyridinium chloride
- EC Number:
- 204-593-9
- EC Name:
- Cetylpyridinium chloride
- Cas Number:
- 123-03-5
- Molecular formula:
- C21H38N.Cl
- IUPAC Name:
- cetylpyridinium chloride
- Reference substance name:
- CPC
- IUPAC Name:
- CPC
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test Substance Identification: Cetylpyridinium Chloride
Lot #00217966
Purity: 100.1% by assay.
Test Substance Description: White powder
Date Received: January 12, 2005
PSL Reference No: 050112-ID
Study Initiation Date: January 24, 2005
Dates of Test: March 9-14, 2005
Notebook No: 05-11: Pages 206-208, 209-209A, 210-216
Constituent 1
Constituent 2
Constituent 3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Housing: The animals were singly house in suspended stainless steel caging
Animal Room Temperature Range: 20-22 Degrees C
Photoperiod: 12-hour light/dark cycle
Food: Pelleted Purina Rabbit Chow #5326
Acclimation Period: 7 days
Water: Filtered tap water was supplied ad-libitum by an automatic water dispensing system
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- One-tenth of a milliliter (0.04 grams) of the test substance was instilled into the conjunctival sac of the right eye of each rabbit.
- Duration of treatment / exposure:
- Full duration of the study
- Observation period (in vivo):
- 1, 24, 48, and 72 hours and at 4 days post-instillation throughout 14 days
- Number of animals or in vitro replicates:
- 3 Males
- Details on study design:
- Test substance was instilled into the conjunctival sac of the right eye of each rabbit by pulling the lower lid away from the eyeball. The upper and lower lids were then gently held together for about one second before releasing to minimize loss of the test substance. No rinsing of the eye occurred. Ocular irritation was evaluated using a high-intensity white light (Mag Lite) in accordance with Draize et al.
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 4 days
- Score:
- > 86 - < 88
- Max. score:
- 88
- Reversibility:
- not reversible
- Remarks on result:
- other: Study terminated and animals euthanized at 4 days
- Irritant / corrosive response data:
- All three animals exhibited corneal opacity, iritis and conjunctivitis. The overall severity increased through 48 hours, and remained extreme at 4 days post treatment. The Maximum Mean Total Score of Cetylpyridinium Chloride is 86.7. The animals were euthanized at day 4 for humane reasons.
- Other effects:
- One animal exhibited reduced fecal volume on Test Day 5. The other two animals appeared active and healthy during the entire observation period.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Draize score > 80 (of 110) from days 2-4 Criteria used for interpretation of results: EU
- Conclusions:
- CPC, when instilled into the eyes of three rabbits, caused severe eye damage (corneal opacity, iritis and conjuctiveity).
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