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EC number: 407-410-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 21, 1990 to July 05, 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
- EC Number:
- 407-410-2
- EC Name:
- 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
- Molecular formula:
- C28H40O8
- IUPAC Name:
- 2-[({5-[(2-carboxycyclohexanecarbonyloxy)methyl]tricyclo[5.2.1.0²,⁶]decan-8-yl}methoxy)carbonyl]cyclohexane-1-carboxylic acid; 2-[({8-[(2-carboxycyclohexanecarbonyloxy)methyl]tricyclo[5.2.1.0²,⁶]decan-4-yl}methoxy)carbonyl]cyclohexane-1-carboxylic acid
- Reference substance name:
- TCD- emulsifier
- IUPAC Name:
- TCD- emulsifier
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): TCD-Emulgator; Tricyclododecandioldihexahydrophtalatdicarbonacid)
- Physical state: solid
- Analytical purity: 95.7 %
- Impurities (identity and concentrations): TCD-Diol: 0.6 % (w/w), Hexahydrophtalsäure: 1.3 % (w/w)
- Purity test date: Apr. 18, 1990-May 04, 1990
- Lot/batch No.: 90003
- Expiration date of the lot/batch: Jan. 08, 1992
- Storage condition of test material: At room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen
- Age at study initiation: males: about 8 weeks, females: about 10 weeks
- Weight at study initiation: males: 188 g, females: 179 g (mean deviation < 20 % for both)
- Fasting period before study: 16 hours before and up to 4 hours after application
- Housing: groups of 5 under conventional conditions
- Diet: fixed-formula standard diet
- Water: ad libitum
- Acclimation period: 6 days before application
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 50 ± 10 %
- Air changes (per hr): approximately 10
- Photoperiod (hrs dark/hrs light): 12 hrs dark/12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): Constant application volume = 10 ml/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Inspection: twice daily (once on weekends and holidays), several times on day of administration; weighing: once a week until end of observation period
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal died during the 14-day observation period.
- Clinical signs:
- After single administration of 2000 mg/kg no clinical signs were observed.
- Body weight:
- Growth was not retarded in male and female rats.
- Gross pathology:
- There were no gross pathological findings in any of the male and female animals of the dose 2000 mg/kg sacrificed at the end of study.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the observation that no acute toxic effects were observed during the present study the test item is not classified.
- Executive summary:
- In an acute oral toxicity study, groups of 8 week old male and 10
week old female Wistar rats (5/sex) were given a single oral dose of the
test item in polyethylene glycol 400 at 2000 mg/kg bw and observed for 14
days.
No mortality occurred at the limit dose of 2000 mg/kg bw.
The test item not classified toxic based on a LD0 ≥ 2000 mg/kg.
There were no treatment related clinical signs, necropsy findings or changes in body weight.
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