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EC number: 943-024-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substance Act (FHSA)
- Version / remarks:
- Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics Assoc, Food and Drug Officials of the US, 2nd printing, Topeka, Kansas, 1965. In accordance with Section 1500.42 Chapter 2, Title 16 Code of Federal Regulations under the Federal Hazardous Substances Act
- Principles of method if other than guideline:
- Test material instilled undiluted into the conjunctival sac of six rabbits. The eyes of some treated animals were not washed following exposure and other animals had their eyes washed after 20 seconds of exposure. Exposure was followed by 14 days of observation and the grade of occular reaction, based on the scoring scale of Lehman et al 1965 (US FDA), recorded at prescribed intervals. A maximum average score for washed and unwashed eyes was calculated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ammonium (xylenes and 4-ethylbenzene) sulphonate
- EC Number:
- 943-024-5
- Molecular formula:
- C8H13NO3S
- IUPAC Name:
- Ammonium (xylenes and 4-ethylbenzene) sulphonate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: SLK, Per-DOT, Issac's
- Age at study initiation: young adult
- Weight at study initiation: no data
- Housing: individually in metal cages elevated above the droppings
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light):no data
IN-LIFE DATES: From:April 23, 1979 To: May 7, 1979
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL in one eye of each animal (the other eye was not treated and served as a control)
- Concentration (if solution): undiluted
VEHICLE
- Amount(s) applied (volume or weight with unit): no vehicle - Duration of treatment / exposure:
- 6 of the 9 animals were treated and their eyes were not washed. The remaining 3 animals had their eyes washed for one minute following 20 seconds of exposure.
- Observation period (in vivo):
- All animals (both eyes) at 1, 24, 48, 72 and 96 hours; and at 7, 10 and 14 days
- Number of animals or in vitro replicates:
- 9 total; six with eyes not washed and 3 with eyes washed
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 3 of 9 animals. One minute washing.
- Time after start of exposure: 20 seconds
- All animals were immobilized in a suitable restrainer rack for one hour following treatment
SCORING SYSTEM: scale for scoring as outlined by Lehman, A.J. et al. in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Association of Food and Drug Officials of the United States, 1965.TOOL USED TO ASSESS SCORE: fluorescein sodium 2% on the cornea
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks:
- 7 days
- Irritant / corrosive response data:
- Rabbits with treated eyes that were not washed produced within 24 hours conjunctival lesions in the form of a moderate erythema of the palpebral and bulbar conjunctivae, a slight to moderate chemosis of the lids, a slight to moderate watery-mucoid discharge and a slight corneal opacity (4 of the 6 animals) involving one-fourth of less of the corneal surface. The test eyes showed steady improvement with the cornea of all test eyes being reaction free at 72 hours. A maximum average score of 13.7 was recorded at 24 hours.The rabbits with washed eyes following treatment produced within 24 hours conjunctival lesions in the form of a slight erythema of the palpebral and bulbar conjunctivae, a moderate chemosis of the lids, a slight watery-mucoid discharge and a slight corneal opacity involving one-fourth to one-half of the corneal surface. Little change was noted at 48 hours and some deduction of the reaction was noted at 72 hours. The corneal reaction was not present at 96 hours and all test eyes were reaction free by 10 days. A maximum average score of 17.3 was recorded at 48 hours.
- Other effects:
- None reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Irritant
- Executive summary:
The eye irritation of Ammonium (xylenes and 4-ethylbenzene) sulfonates was assessed following official guideline Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics Assoc, in accordance with Section 1500.42 Chapter 2, Title 16 Code of Federal Regulations under the Federal Hazardous Substances Act. The results showed effects on eye. Rabbits with treated eyes that were not washed produced within 24 hours conjunctival lesions in the form of a moderate erythema of the palpebral and bulbar conjunctivae, a slight to moderate chemosis of the lids, a slight to moderate watery-mucoid discharge and a slight corneal opacity (4 of the 6 animals) involving one-fourth of less of the corneal surface. The test eyes showed steady improvement with the cornea of all test eyes being reaction free at 72 hours. A maximum average score of 13.7 was recorded at 24 hours. The rabbits with washed eyes following treatment produced within 24 hours conjunctival lesions in the form of a slight erythema of the palpebral and bulbar conjunctivae, a moderate chemosis of the lids, a slight watery-mucoid discharge and a slight corneal opacity involving one-fourth to one-half of the corneal surface. Little change was noted at 48 hours and some deduction of the reaction was noted at 72 hours. The corneal reaction was not present at 96 hours and all test eyes were reaction free by 10 days. A maximum average score of 17.3 was recorded at 48 hours.
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