Registration Dossier
Registration Dossier
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EC number: 200-254-4 | CAS number: 56-06-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Test material
- Reference substance name:
- 2,6-diamino-1H-pyrimidin-4-one
- EC Number:
- 200-254-4
- EC Name:
- 2,6-diamino-1H-pyrimidin-4-one
- Cas Number:
- 56-06-4
- Molecular formula:
- C4H6N4O
- IUPAC Name:
- 2,6-diamino-1H-pyrimidin-4-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Observation period (in vivo):
- 72h
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Investigation with fluorescein was performed.
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- other: all three animals
- Time point:
- other: 24, 48 and 72h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48h
Any other information on results incl. tables
| Mean Score (mean of 24, 48 and 72h) | Maximum Value | Maximum Duration of Any Effect | Maximum Value at End of Observation Period | |||
| Findings | Animal No.1 | Animal No.2 | Animal No.2 | |||
| Conjunctiva: redness | 1 | 1 | 1 | 2 | 48 h | 0 |
| Conjunctiva: chemosis | 0 | 0.33 | 0.33 | 1 | 24 h | 0 |
| Conjunctiva:discharge** | - | - | - | - | not applicable | |
| Corneal opacity | 0 | 0 | 0 | 0 | not applicable | 0 |
| Iris | 0 | 0 | 0 | 0 | not applicable | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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