Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-987-8 | CAS number: 112-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute toxicity to Daphnia was experimentally determined to be EC50(48h) = 0.194 mg/L. The respective chronic effect concentration based on the OECD 211 for reproduction was determined to be EC10(21d) = 0.0136 mg/L. For the toxicity towards algae, the 72h-ErC50 and 72h-ErC10 values were determined to be > 0.067 mg/l and 0.0385 mg/l, respectively. The acute toxicity towards fish was experimentally determined with an LC50(96h) of 2.02 mg/l. The chronic toxicity towards fish was predicted to be 30d-NOEC = 0.031 mg/l.
The available acute aquatic EC50 (Daphnia) and chronic aquatic EC10 (Daphnia) were used as basis for the aquatic classification.
Additional information
In addition to the experimental results, a QSAR model (Ecological Structure-Activity Relationship (ECOSAR) version 1.11) was used to predict the aquatic toxicity of dihexyl ether resulting in the following effect concentrations:
Acute Algae 96h-EC50 = 0.562 mg/l
Chronic Algae 96h-ChV = 0.272 mg/l (96h-NOEC = 0.192 mg/l)
Acute Daphnia 48h-LC50 = 0.242 mg/L
Chronic Daphnia 21d-ChV = 0.051 mg/l (21d-NOEC = 0.036 mg/l)
Acute Fish 96h-LC50 = 0.324 mg/l
Chronic Fish 30d-ChV = 0.044 mg/l (30d-NOEC = 0.031 mg/l)
The calculated values are based on the calculated logKow value. The calculated acute Daphnia LC50 reflects the experimentally determined EC50 value and also the calculated result for fish is in the same range as the Daphnia results. The calculated algae-NOEC is almost an factor of 10 higher than the experimentally determined ErC10 value. Due to the low solubility and volatility of dihexyl ether it is highly likely that the experimental value is considerably lower as the ECx calculations are based on the measured geo. mean values to account for the decrease of test substance concentration over the course of the test.
Nevertheless the calculated results for the acute toxicity towards fish, as well as the calculated results for chronic toxicity towards fish are considered reliable, as fish does not appear to be the most sensitive species.
The available acute aquatic EC50 (Daphnia) and chronic aquatic EC10 (Daphnia) were used as basis for the aquatic classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.