Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 240-032-4 | CAS number: 15894-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Adequate reliable measured data exists for short-term toxicity to fish for HMBDA and has been documented within this dossier. The most reliable study result for the test substance has been identified as a study (Holland et al. 1993) which reports an LC50 for short term toxicity in fish of >13 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for HMBDA.
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with fish available with HMBDA. However, a waiver is applied for this endpoint on the basis of low solubility, minimal exposure to aquatic organisms and no adverse effects to fish are expected.
A reliable (Klimisch 1) short-term toxicity study with invertebrates has been conducted for HMBDA and is included in this dossier. The key study, Kent et al. (1993), provides a 48-hr LC50 of >21 mg/L forDaphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate’s endpoint for HMBDA.
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with HMBDA. However, a waiver is applied for this endpoint on the basis of low solubility and minimal exposure.
Adequate reliable measured data exists for toxicity of HMBDA to algae. The data point of highest concern for this endpoint has been identified in a reliable study which reports a measured 72 hr EC50 of 17 mg/L and 72 hr NOEC of 2.5 mg/L, based on growth, for toxicity to aquatic algae. Consequently these values will be taken as the toxicity in aquatic algae endpoint for HMBDA.
There are no reliable toxicity data for microoganisms with HMBDA. A waiver is applied for this endpoint on the basis of low to insoluble nature of the test substance and minimal exposure as the substance is an intermediate product and manufactured and utilized only at one location in the EU and handled under strictly controlled conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.