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Diss Factsheets
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EC number: 207-329-0 | CAS number: 462-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Read-across
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Hexamethylenediamine
- EC Number:
- 204-679-6
- EC Name:
- Hexamethylenediamine
- Cas Number:
- 124-09-4
- Molecular formula:
- C6H16N2
- IUPAC Name:
- hexane-1,6-diamine
- Details on test material:
- - Name of test material (as cited in study report): hexamethylenediamine
- Molecular formula (if other than submission substance): C6H16N2
- Molecular weight (if other than submission substance): 116.2046
- Smiles notation (if other than submission substance): NCCCCCCN
- InChl (if other than submission substance): InChI=1/C6H16N2/c7-5-3-1-2-4-6-8/h1-8H2
- Structural formula attached as image file (if other than submission substance): see Fig.1
- Substance type: organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ONCINS, IFFA CREDO
- Age at study initiation: no data
- Weight at study initiation: 130 to 160g
- Fasting period before study: no data
- Housing:no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: no data
- Doses:
- 900, 1170, 1530 and 2000mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: animals in the higher non-lethal dose group were weighed once every 5 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- method of Litchfield and Wilcoxon.
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 160 mg/kg bw
- Remarks on result:
- other: 95% C.L: no data
- Mortality:
- See Table 7.2.1/1
- Clinical signs:
- other: For all doses: cries after treatment and excessive salivation. A decrease of the motor activity was observed at dose level of 1170 and 900 mg/kg bw.
- Gross pathology:
- At dose levels of 2000 and 1530 mg/kg bw, for all died animals, an ulceration of all the surface of the gastric mucous membrane was noted and also the presence of blood in the intestine was observed.
At dose level of 2000 mg/kg bw, for the surviving animal, an ulceration of the 3/4 mucous membrane was observed, with a thickening and an adherence to spleen, stomach and abdominal wall.
At dose level of 1530 mg/kg bw, one surviving animal presented the same lesions of the surviving animal at dose level of 2000 mg/kg bw, and the other surviving animal not presented any lesion.
At dose level of 1170 mg/kg bw, for the 7 died animals, an ulceration of the pylore was noted. No lesions were observed for the surviving animals.
At dose level of 900 mg/kg bw, no lesions were observed. - Other findings:
- No data
Any other information on results incl. tables
Table 7.2.1/1 Number of animals dead and time range within which mortality occured
Dose (mg/kg/bw) |
Mortality (# dead/total) |
Time range o f deaths (hours) |
||
Male |
Female |
Combined |
||
Control |
- |
- |
- |
- |
900 |
- |
- |
01/10 |
D6 |
1170 |
- |
- |
07/10 |
D2-D4 |
1530 |
- |
- |
08/10 |
D0-D12 |
2000 |
- |
- |
09/10 |
D0-D4 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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