Registration Dossier
Registration Dossier
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EC number: 200-879-2 | CAS number: 75-56-9
Endpoint summary
Administrative data
Description of key information
Additional information
A GLP-compliant guideline study (EPA-660/3-75-009) is available for propylene oxide, reporting a 96 h LC50 value of 52 mg/L in the freshwater species Salmo gairdneri (new name: Oncorhynchus mykiss) (Shell Research Ltd., 1986). The only saltwater species reported is the common mullet (Mugil cephalus) which shows a similar sensitivity to the freshwater species, having a 96 h LC50 of 89 mg/L (Crews, 1974).
Due to the fact that the substance is considered ready biodegradable, no significant concentrations are present in the water compartment. This is supported by exposure assessment with EUSES. The maximal local PEC value that was calculated was 2.31.10-3mg/L for freshwater and 8.65.10-4mg/L for seawater. Since these concentrations are very low, no significant long term exposure of fish and aquatic invertebrates is assumed and therefore long-term toxicity tests with fish and aquatic invertebrates are not needed.
A GLP-compliant guideline study ( EPA-660/3-75-009) is available for propylene oxide, reporting a 48 h EC50 value of 350 mg/L in the freshwater species Daphnia magna (Shell Research Ltd., 1986).
No long-term aquatic toxicity studies in fish and/or invertebrates are available for propylene oxide.
A GLP-compliant guideline study (EPA-660/3-75-009) is available for propylene oxide reporting a 96 h EC50 value of 240 mg/L based on growth rate in the freshwater species Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata) (Shell Research Ltd., 1986).
There are no toxicity studies available for the effects of propylene oxide on microorganisms. However, there was no measurable inhibition of microbial activity in the closed bottle test (GLP, OECD 301D) at 3 mg/L after 28 days exposure (Shell Research Ltd., 1985).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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