Registration Dossier
Registration Dossier
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EC number: 258-904-8 | CAS number: 53988-10-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of methylmercaptobenzimidazole
- Author:
- Bomhard E, Loeser E
- Year:
- 1 996
- Bibliographic source:
- J Am Coll Toxicol 15, S65
Materials and methods
- Principles of method if other than guideline:
- Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
- EC Number:
- 258-904-8
- EC Name:
- 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
- Cas Number:
- 53988-10-6
- Molecular formula:
- C8H8N2S
- IUPAC Name:
- 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
- Details on test material:
- Versuchsprodukt KA 9059 = Vulkanox MB-2/MG; no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 200, 300, 350, 380, 400, 450, or 500 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 340 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 1 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14.
Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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