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Diss Factsheets
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EC number: 201-607-5 | CAS number: 85-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation, mixed exposure
Data source
Reference
- Reference Type:
- publication
- Title:
- Phthalic anhydride-induced occupational asthma
- Author:
- Wernfors M, Nielsen J, Schuetz A, Skerfving S
- Year:
- 1 986
- Bibliographic source:
- Int. Arch. Allergy Appl. Immun. 79, 77-82.
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- case report
- Principles of method if other than guideline:
- out of 118 workers exposed to phthalic anhydride 46 male and 2 female subjects were studied. physical examination and spirometry, skin-prick test were performed. 2 asthmatic subjects were submitted to bronchial provocation with PA dust
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Method
- Type of population:
- occupational
- Controls:
- no data
- Route of administration:
- inhalation
Results and discussion
- Results of examinations:
- The average concentration of phthalic anhydride dust at the workplaces was given as 3-13 mg/m3, of which 40-46% was in the inspirable dust fraction. Out of 118 workers exposed occasionally to phthalic anhydride dust for 2 months or more, 28 (24%) suffered from work-related rhinitis, 13 (11%) from chronic productive bronchitis, and 21 (28%) from work-associated asthma. Three out of eleven asthmatics had a phthalic anhydride-positive skin test, and in two subjects the presence of antibodies was demonstrated.
Any other information on results incl. tables
The latency period between start of employment and onset of respiratory symptoms ranged from 1 month to 16 years. in 8 cases (38%) astma started after a couple of month or less
Applicant's summary and conclusion
- Executive summary:
Out of 118 workers exposed to phthalic anhydride 46 male and 2 female subjects were studied. physical examination and spirometry, skin-prick test were performed. 2 asthmatic subjects were submitted to bronchial provocation with PA dust.
The average concentration of phthalic anhydride dust at the workplaces was given as 3-13 mg/m³, of which 40-46% was in the inspirable dust fraction. Out of 118 workers exposed occasionally to phthalic anhydride dust for 2 months or more, 28 (24%) suffered from work-related rhinitis, 13 (11%) from chronic productive bronchitis, and 21 (28%) from work-associated asthma. Three out of eleven asthmatics had a phthalic anhydride-positive skin test, and in two subjects the presence of antibodies was demonstrated.
reference: Wernfors, 1986
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