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Diss Factsheets
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EC number: 215-863-0 | CAS number: 1435-71-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- publication
- Title:
- In-silico screening of high production volume chemicals for mutagenicity using the MCASE QSAR expert system
- Author:
- Klopman, G., Chakravarti, S.K., Harris, N., Ivanov, J. and Saiakhov, R.D.
- Year:
- 2 003
- Bibliographic source:
- SAR and QSAR in Environmental Research, 14(2), 165-180
Materials and methods
- Principles of method if other than guideline:
- The MCASE-program, a quantitative structure-activity relational expert system (QSAR-ES), was used in this study. The program identifies structural features believed to be responsible for activity and is particularly suitable for handling large databases with diverse chemical sturctures. Previous experience has shown that the Salmonella assay is well adapted for use in computer expert systems for mutagenicity prediciton. Results are presented for batch screening of 2484 HPV chemicals to predict their mutagenicity in Salmonella thyphimurium. The chemicals were tested against 15 databases for salmonella strains TA 100, TA 1535, TA 1537, TA 97 and TA 98, both with metabolic activation (using rat liver and hamster liver S9 mix test) and without metabolic activation.
- GLP compliance:
- no
- Type of assay:
- other: QSAR
Test material
- Reference substance name:
- 2-[(o-nitrophenyl)azo]-p-cresol
- EC Number:
- 215-863-0
- EC Name:
- 2-[(o-nitrophenyl)azo]-p-cresol
- Cas Number:
- 1435-71-8
- Molecular formula:
- C13H11N3O3
- IUPAC Name:
- 4-methyl-2-[(2-nitrophenyl)diazenyl]phenol
- Details on test material:
- - Name of test material (as cited in study report): Phenol, 4-methyl-2-[(2-notrophenyl)azo]-
Constituent 1
Method
- Target gene:
- his-
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA 100, TA 1535, TA 1537, TA 97 and TA 98
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat and hamster liver metabolic activation
- Evaluation criteria:
- The result for a test of one chemical against an individual strain was categorized as "active", "inactive", or "marginal". These three possible outcomes were assigned scores of 2.0 (active), -1.0 (inactive) and 0.0 (marginal). Chemicals that were predicted as active with only a low degree of statistical certainty were categorized as "equivocal active" and assigned a score of 1.0. Similarly, an "equivocal inactive" result is assigned a score of -0.5. For each chemical, three composite scores were computed: (1) sum of individual scores for each of the five Salmonella strain modules without metabolic activation; (2) sum of scores for five modules with rat liver metabolic activation and (3) sum of scores for five modules with hamster liver metabolic activation.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA 100, TA 1535, TA 1537, TA 97 and TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
Any other information on results incl. tables
The scores for Phenol, 4-methyl-2-[(2-nitrophenyl)azo]- were:
(1): 3.0;
(2): 1.0;
(3): 4.0;
In this assessment, phenol, 4-methyl-2-[nitrophenyl)azo]- was in the group of chemicals that surfaced as possible mutagens. The chemicals in this group are expected to be highly mutagenic.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.