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Diss Factsheets
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EC number: 434-850-2 | CAS number: 1680-31-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-09-22 to 1999-10-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- January 1997
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals:
- Source: Tierzucht Schönwalde GmbH, D-16352 Schönwalde, Germany
- Weight at study initiation: 206 - 240 g
- Fasting period before study: no
- Housing: transparent polycarbonate cages (macrolone type ID, floor area 810 sq. cm) with two or three in each cage, males and females separated. The cages were cleaned and the bedding changed at least twice a week.
- Diet: pelleted complete rodent diet "Altrornin 1314" from Altromin GmbH, D-32791 Lage, Lippe, was available ad libitum
- Water: domestic quality drinking water acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth
- Acclimation period: 7 days
Environmental conditions:
- Temperature: 21 +/- 3 °C
- Humidity: 55 % +/-15 %
- Air changes: 10 tirnes per hour
- Photoperiod: 12 hours light and 12 hours darkness, light from 6 am to 6 pm
In-life dates:From 1999-09-22 to 1999-10-07
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Test site:
- Area of exposure: 5 x 6 cm
- Type of wrap if used: 4-layer gauze pack fixed with Micropore tap
Removal of test substance after 24 h:
- Washing: lukewarm water
- Time after start of exposure: 24 h
Test material:
- Amount applied: 5000 mg/kg bw
Vehicle: none - Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males/5 females per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation: 1, 3 and 6 hours after dosing and thereafter daily for a period of 14 consecutive days; weighing: on day 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- NA
Results and discussion
- Preliminary study:
- Prior to the main study a pilot study was performed using one male rat given 2000 mg/kg bw and one female rat given 5000 mglkg bw. Very slight signs of toxicity were observed in these rats. On the basis of the results of the pilot study it was decided to carry out the main study with one group consisting of five male and five female rats given a dose of 5000 mg/kg bw.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Neither male nor female rats died at this dose level nor did they show marked signs of toxicity during the study period.
- Clinical signs:
- other: Male: One hour after the application all animals showed piloerection. All further observations after 3 and 6 hours and from day 1 until the end ofthe observation period revealed no abnormalities. Female: One hour after the application all animals showed
- Gross pathology:
- The post martern inspection revealed no abnormalities.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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