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EC number: 231-793-3 | CAS number: 7733-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Zinc Intoxication: Comparison of the Antidotal Efficacy of Several Chelating Agents
- Author:
- Domingo J L, Llobet J M, Paternain J L and Corbella J
- Year:
- 1 988
- Bibliographic source:
- Vet Hum Toxicol 30(3): 224-228
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was administered to mice intraperitoneally for 14 d to determine the acute intraperitoneal LD50.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Zinc sulphate
- EC Number:
- 231-793-3
- EC Name:
- Zinc sulphate
- Cas Number:
- 7733-02-0
- Molecular formula:
- H2O4S.Zn
- IUPAC Name:
- zinc sulfate
- Details on test material:
- - Name of test material: Zinc sulphate (purchased from E Merck (Darmstadt, FRG)
- Other: Source - E Merck (Darmstadt, FRG)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Panlab (Barcelona, Spain)
- Age at study initiation: No data
- Weight at study initiation: 24-28 g
- Fasting period before study: No data
- Housing: No data
- Diet: Standard pellet diet (Panlab, Barcelona, Spain), ad libitum
- Water: Tap water, ad libitum
- Acclimation period: 7 d
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- DOSAGE PREPARATION: Solutions were administered at pH between 6.0 and 7.0. Sodium bicarbonate was used to adjust the pH when necessary.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: A preliminary screening with small groups of 3 animals was carried out. The LD50 values were then calculated according to the Litchfield and Wilcoxon method. - Doses:
- No data
- No. of animals per sex per dose:
- Preliminary screening: Three
Main study: Ten - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No
- Other examinations performed: Clinical signs and weight gain - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 316 mg/kg bw
- 95% CL:
- 205 - 488
- Remarks on result:
- other: Equivalent to 115 mg of Zn/kg
- Mortality:
- Mortality occurred mostly during the first 48 h of the test material administration. No deaths occurred after three days.
- Clinical signs:
- Conjunctivitis, piloerection, decreased food and water consumption and hemorrhages and hematomas in the tail were observed in the treated animals. These clinical signs appeared within the first 48 h and decreased/disappeared with time.
See Table 1 in "Remark on results including tables and figures" field - Body weight:
- Slight weight loss
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
Table 1. Severity of physical and clinical signs in mice after zinc intoxication in a single dose
|
Number of days after zinc administration |
|||
1 |
2-3 |
4-7 |
8-14 |
|
Mortality rates on intraperitoneal administration |
90% |
10% |
0% |
0% |
Conjunctivitis |
None |
+ |
+ |
None |
Piloerection |
None |
+ |
+ |
+ |
Hemorrhages and hematomas in the tail |
None |
+ |
+++ |
+++ |
Degreased food and water consumption, weight loss |
None |
+ |
+ |
None |
Mortality rates and physical and observational examination of rats are average for all zinc compounds.
+Light; ++Moderate; +++Severe
Applicant's summary and conclusion
- Conclusions:
- Based on the above results, the acute intraperitoneal LD50 of the test material in Swiss albino mice was determined to be 316 mg/kg (equivalent to 115 mg of Zn/kg).
- Executive summary:
A study was conducted to evaluate the acute intraperitoneal toxicity of the test material in Swiss albino mice.
Initially a preliminary screening with small groups of three mice was carried out and the LD50 values were then calculated according to the Litchfield and Wilcoxon method. In the main study, the test substance was administered in ten mice.
Mortality was observed mostly during the first 48 h after test material administration. Conjunctivitis, piloerection, hemorrhages, hematomas in tail and decreased food and water consumption were observed in the treated mice.
Based on these results, the acute intraperitoneal toxicity of LD50 was determined to be 316 mg/kg (equivalent to 115 mg of Zn/kg).
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