Registration Dossier
Registration Dossier
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EC number: 202-704-5 | CAS number: 98-82-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the EU RAR (2001; section 4.1.2.5, page 56) it was concluded that cumene did not cause any signs of skin sensitisation in the tests conducted.
Experimental studies
No skin sensitisation was noted among a group of 20 female guinea pigs treated with cumene in a Magnusson-Kligman maximisation test conducted according to OECD Guideline 406 (see robust study summaries in IUCLDI Section 7.4.1). For induction 0.1 cm³ of a 10% test solution was tested and for challenge the concentration was 40%.
Human data
No information is available.
Migrated from Short description of key information:
As a result of an OECD Guideline study cumene is not sensitising.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
Regarding respiratory sensitisation there is no information available.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
