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EC number: 202-679-0 | CAS number: 98-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
ptBP was found to be acutely toxic to fish (rainbow trout) with an approximate 96h-LD50 value of 5.1 mg/L.
Key value for chemical safety assessment
Additional information
An acute toxicity study was performed to assess the acute aquatic toxicity of ptBP to rainbow trout (Oncorhynchus mykiss) for a period of 96 hours (SafePharm, 1991). The study followed the OECD Guidelines for Testing of Chemicals No. 203. A preliminary range-finding study was conducted with rainbow trout (2 fish/concentration) at nominal test concentrations of 0.01, 0.1 and 1.0 mg/L. The concentration of 1 mg/L was the highest test concentration prepared due to the limited solubility of the test material in water and auxiliary solvent. In the definitive study, a limit test was conducted at a nominal concentration of 1 mg/L in two replicates (10 fish/replicate). In parallel, a control and a solvent control (10% Tween-80-dimethylformamide) group were also tested. No mortality occurred at any of the tested concentrations. The LC50 at 96 hours exposure was determined to be greater than 1 mg/L.
Aquatic toxicity of ptBP was also determined in a flow-through test with fathead minnow (Pimephales promelas) (Holcombe et al., 1984, cited in the EU Risk Assessment). No test guidelines were followed; however, the test was performed in a US EPA lab, suggesting that US EPA standards may have been followed. There were 5 test concentrations; measured mean concentrations were 1.16, 1.87, 3.1, 5.44, and 9.47 mg/L, giving a mean recovery of 99%. PtBP were tested as one of 24 organic compounds and specific test conditions for the test with ptBP were not included. The 96h-LC50 value was determined to be 5.14 mg/L, based on measured concentrations.
In a semi-static toxicity study with Oryzias latipes, conducted in accordance with the OECD Guidelines for Testing of Chemicals No 203, a 96 h-LC50 value of 5.1 mg/L was determined for ptBP, based on nominal concentrations (EA of Japan, 1996, cited in the EU Risk Assessment). DMSO was used as a solubilizer, to increase the solubility of the test material.
In a similar semi-static study using Oryzias latipes, performed according to the Japanese standard JISK 0102-1986-71, the 48h-LC50 was determined to be 4.0 mg/L for ptBP, based on nominal concentrations (MITI, 1992, cited in the EU Risk Assessment). This study, however, is not considered to be valid as the test period was 48 hours instead of 96 hours exposure.
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