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Diss Factsheets
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EC number: 218-216-0 | CAS number: 2082-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
absorprtion and effective excretion within 168hrs
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The distribution and excretion of C-labelled test substance was determined in the oral-gavage study in rats (CIBA-GEIGY, 1977). Four male rats were administered with 14C-test substance (specific gravity of 8.52 µCi/mg; radiochemical purity >99%) in a single oral-gavage dose of 10 mg/kg bw. The elimination of radioactivity and its retention was determined up to 168 h post administration. The distribution results showed highest residual radioactivity in the heart (0.54 µg/g). Slightly higher levels than blood (0.07 µg/g) showed thyroid, liver, kidney, brown/white fat and aorta (0.21-0.09 µg/g). In all other organs and tissues lower but still detectable levels were found. Within 0-48 hours after administration about 73% of the dose was eliminated from the body. Afterwards elimination proceeded slowly and was not fully completed at 168 hours. At that time 96% of the dose was recovered, 35% in the urine and 61% in the faeces.
In another study (GEIGY 1965), absorption of the C-labelled test substance was evaluated by the Levine technique in one rat. The substance was directly injected into the ligated gut lumen. After 3 hours, the ligated intestinal segment was removed and the amount of compound present was determined. The results showed 31.6 to 55.9 % absorption.
Combining all results, the test was well absorbed within 3 hours and almost fully (96%) eliminated with 168 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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