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Diss Factsheets
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EC number: 209-008-0 | CAS number: 552-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-07-09 to 1991-07-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Proprietary non-guideline study, the study was not conducted according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- There is no information on test material, on animals (such as housing conditions, strain, age, weight, source etc). There is no indication as to whether or not the test article was removed after instillation. It was not indicated as to whether or not the test article was ground as a fine dust when placed in the conjunctival sac.
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
- EC Number:
- 209-008-0
- EC Name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
- Cas Number:
- 552-30-7
- Molecular formula:
- C9H4O5
- IUPAC Name:
- 1,3-dioxo-1,3-dihydro-2-benzofuran-5-carboxylic acid
- Details on test material:
- No information available.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No further information available.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- Single administration of test substance to eye
- Observation period (in vivo):
- The eye of the rabbit was examined at 1 and 24 hours after application
- Number of animals or in vitro replicates:
- 1 male rabbit
- Details on study design:
- 0.1 g of test material was applied to the right eye of 1 male rabbit, the left eye remained untreated to serve as a control. In the interests of animal welfare, only 1 male rabbit was used as it was assumed that trimellitic anhydride would be a severe eye irritant.
The eye irritation was scored according to the Draize method
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Signs of ocular irritation were maximum at 24 hours after application and the study was terminated immediately thereafter.
- Other effects:
- No other effects reported.
Any other information on results incl. tables
Table 1: Summary of eye irritation scores in one male rabbit
Time |
Cornea |
Iris |
Conjunctiva |
|||
|
Density of opacity |
Area of opacity |
|
Erythema |
Chemosis |
Discharge |
1 hour |
4 |
4 |
2 |
2 |
3 |
2 |
24 hour |
4 |
4 |
2 |
3 |
4 |
3 |
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Trimellitic acid (TMA) is considered a severe eye irritant. TMA is classified as irritating with the symbol Xi and is assigned the risk phrase R41 " Risk of serious damage to eyes" according to Regulation (EC) No 1272/2008. It is classified as Category 1 for serious eye damage with the signal word "Danger" and is assigned the hazard statement H318 "causes serious eye damage" according to Regulation (EC) No 1272/2008
- Executive summary:
The study investigated the eye irritant effects of the test material in 1 male rabbit. 0.1 g of trimellitic anhydride was administered to the right eye of one male rabbit. The left eye served as the untreated control. The treated eye was examined at 1 and 24 hours after application of the test material. The control eye was used for comparison.
Signs of ocular irritation were maximum at 24 hours after application and the study was terminated immediately thereafter. On this basis, trimellitic anhydride is considered a severe eye irritant. TMA is classified as irritating with the symbol Xi and is assigned the risk phrase R41 " Risk of serious damage to eyes" according to 67/548/EEC. It is classified as Category 1 for serious eye damage with the signal word "Danger" and is assigned the hazard statement H318 "causes serious eye damage" according to Regulation (EC) No 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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