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Diss Factsheets
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EC number: 231-673-0 | CAS number: 7681-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reasonably well-documented short communication on changes in the clearing mechanism due to sulphite exposure.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Long-term exposure of dogs to a sulphite aerosol.
- Author:
- Ferron, G.A.; et al.
- Year:
- 1 990
- Bibliographic source:
- J. Aerosol Sci. 21, S479-S482
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eight Beagle dogs were exposed in chambers to an aerosol concentration of 1 mg/m3 Na2S2O5 or 290 days. Prior to this exposure the animals were housed in chambers under clean air conditions for 320 days. Selected parameters of lung clearance, biochemistry, cytology, and morphology were determined during both periods to find sensitive parameters for early changes of lung function. Only changes of lung clearance parameters are described in this paper.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Disodium disulphite
- EC Number:
- 231-673-0
- EC Name:
- Disodium disulphite
- Cas Number:
- 7681-57-4
- Molecular formula:
- Na2S2O5
- IUPAC Name:
- disodium disulphite
- Details on test material:
- - Name of test material (as cited in study report): sodium metabisulfite
- Molecular formula (if other than submission substance): Na2S2O5
- Molecular weight (if other than submission substance): 190.1 g/mol
- Substance type: technical product
- Physical state: solid, white powder
No further details are given.
Constituent 1
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: no data
- Details on inhalation exposure:
- Inhalation conditions are reported in Tuch, T.; et al. (1990): Long-term exposure of dogs to a sulphite aerosol: I. Rationale and design parameters. J. Aerosol Sci. 21.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 320 days exposure to clean air (control period) followed by 290 days exposure to Na2S2O5 aerosol (exposure period)
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1mg Na2S2O5 /m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- 8 dogs in total
- Control animals:
- other: dogs served as their own conrol
- Details on study design:
- no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: No data
FOOD CONSUMPTION: No data
FOOD EFFICIENCY: No data
WATER CONSUMPTION: No data
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: No
CLINICAL CHEMISTRY: No
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No
OTHER:
- Samples of urine and faeces were collected from each dog in 2-week intervals and analyzed for 57Co and 60Co.
- The particulate fraction of 60Co-FAP in faecal samples was distinguished from the non-particulate 60Co in order to determine directly mechanical particle transport from the lungs to the gut. - Sacrifice and pathology:
- no data
- Other examinations:
- - Selected parameters of lung clearance, biochemistry, cytology, and morphology were determined during both periods to find sensitive parameters for early changes of lung function.
- Only changes of lung clearance parameters are described in this paper (other results are given by "Maier, K.L; et al. (1990). Long-term exposure of dogs to sulphite aerosol: II. Effect on biochemical and cellular lung parameters. J. Aerosol. Sci.21" and "Takenaka, S.P.; et al. (1990). Long-term exposure of dogs to sulphite aerosol: IV. Effects on airway morphometry. J. Aerosol. Sci. 21." ):
- Lung clearance was tested with moderately soluble (57Co3O4) and insoluble aerosol particles (fused aluminosilicate (FAP) tracered with 60Co) after a single inhalation. - Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- OTHER FINDINGS
- Three out of eight dogs showed significant changes in clearance rate of moderately soluble particles during the sulphite exposure compared to the clearance rate during clean air exposure.
- These changes were confirmed by in vitro clearance measurements in alveolar macrophages.
- First indications were found for changes in the mechanical particle transport rates during sulphite exposure.
Effect levels
- Dose descriptor:
- NOAEC
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Only changes of lung clearance parameters are described in this paper. Three out of eight dogs showed significant changes in clearance rate of moderately soluble particles during the sulphite exposure compared to the clearance rate during clean air exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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