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Diss Factsheets
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EC number: 235-759-9 | CAS number: 12656-85-8 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77605.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study (20-hour exposure; only 8-day observation period)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 48, 72 hours and until the end of the observation period. Findings were graded as described in OECD test guideline 404.
- GLP compliance:
- no
Test material
- Reference substance name:
- Lead chromate molybdate sulfate red
- EC Number:
- 235-759-9
- EC Name:
- Lead chromate molybdate sulfate red
- Cas Number:
- 12656-85-8
- Molecular formula:
- Pb (Cr,S,Mo) O4
- IUPAC Name:
- tris(λ²-lead(2+)) dioxochromiumbis(olate) dioxomolybdenumbis(olate) sulfate
- Details on test material:
- - Name of test material (as cited in study report): molybdat red V 15243
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: containing 60% Pb; no additional data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler (1 male and 1 female animals)
- Age at study initiation: young adult animals
- Weight at study initiation: 3.0 kg (2.9 kg at the end) for the male animal, 3.6 kg (3.4 kg) for the female animal
- Diet (e.g. ad libitum): Ssniff
- Water: ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact/shaved and abraded
- Controls:
- other: untreated skin of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): appr. 0.5 test substance wrapped in light wet cloth
- Concentration (if solution): not diluted - Duration of treatment / exposure:
- 20 hours
- Observation period:
- 8 days
- Number of animals:
- 1 male and 1 female animals
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
no specified
SCORING SYSTEM: as described in OECD guideline 404 (readings after 24 hours, 48 hours, 72 hours and 8 days)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-48-72 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: only red to brawn coloration of the skin by test substance was observed. No adverse effects observed
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- The test substance has to be considered as considered as not irritating according to the EU and to GHS
- Other effects:
- The animals showed no erythema or edema formation after exposure to the test substance up to 20 h after removal of the patches A red discoloration of the skin was observed which was due to the intrinsic color of the test material. In case of the 20 h exposure, superficial brown patches were observed at the 24 h and 72 h reading which were reversible within the obeservation period of 8 days and do not represent a lokal skin reaction. Other toxic effects were not observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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