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Diss Factsheets
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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
35 day NOEC 0.16 mg/L (Pimephales promelas)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.16 mg/L
Additional information
The key study is a flow-through long-term toxicity test conducted with fathead minnows (Pimephales promelas) according to U.S. EPA methodologies. Exposure began during the embryo stage and lasted for 35 days. Fish were exposed to 0.024, 0.04, 0.084, 0.16, and 0.31 mg/L TBBPA (mean measured concentrations), with water samples for chemical analysis collected on test days 0, 4, 11, 16, 18, 25, 29, 32, and 35. The 35-day NOEC was determined to be 0.16 mg/L TBBPA, as there was a significant reduction in growth observed in fish exposed at this level. Larval fish survival was significantly reduced at the highest test concentration.
Supporting data is provided in the form of a partial life-cycle test with zebrafish (Danio rerio). Exposure of adult fish to the test material for 30 days at nominal concentrations of 0 (control), 0.023, 0.047, 0.094, 0.188, 0.375, 0.750, 1.50, 3.00, and 6.00 µM under semi-static conditions was followed by exposure of the offspring in early life stages up to 47 days post hatching to the same concentrations.
The study indicates that exposure of zebrafish to the test material can result in effects on population-relevant parameters such as egg production, juvenile survival, and gender development of offspring at test material-body burdens around 5 - 7 µg/g lipid. Although the results could be consistent with the oestrogenic activity of the test material, the extent to which such a mechanism plays a role remains unclear without further supportive evidence. There were no indications for anti-thyroid activity
Under the conditions of this study, the results indicate decreased reproductive success in zebrafish at environmentally relevant test material concentrations.
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