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Diss Factsheets
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EC number: 248-145-0 | CAS number: 26966-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Detailed laboratory report, pre-GLP and guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- sex and strain not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3(or 4)-methylbenzene-1,2-diamine
- EC Number:
- 248-145-0
- EC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Cas Number:
- 26966-75-6
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Details on test material:
- Vicinal isomer mix was maintained, prepared and extracted under a blanket on nitrogen in order that degradation would not occurr.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Animals weight between 200 and 300 g were fed, housed and watered according to lab SOPs.
.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Overnight fast before dosing. Vehicle de-aerated water. Dose was 4% concentration and dosed volume adjusted to deliver the target dose.
- Doses:
- 0, 400, 600, 640, 720, 760, 800 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Animals observed for signs of toxicity and mortality at 1, 3, 6, 24, 48, 72 hours and then daily for total of 14 days.
Autopsies performed on all dead animals. - Statistics:
- LD50 determinations calculated by the method of Miller and Tainter, 1944 (Exptl. Biol. and Med. 57, pp 261 - 264)
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 660 mg/kg bw
- Remarks on result:
- other: S.E. =19
- Mortality:
- No mortality at 400 mg/kg
100% mortality at 800 mg/kg - Clinical signs:
- other: Decreased locomotor activity in all dosed groups in the first 24 hours after dosing Piloerection seen at 600mg/kg and above in the first 24 hours after dosing Ptosis seen at 640mg/kg and above in the first 24 hours after dosing.
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Any other information on results incl. tables
Mortality
mg/kg BW dead/dosed
0 (control) 0/10
400 0/10
600 2/10
640 4/10
720 7/10
760 9/10
800 10/10
Applicant's summary and conclusion
- Executive summary:
LD 50 of vicinal isomer mix was 660 +/- 19 mg/kg BW.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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