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Diss Factsheets
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EC number: 907-605-7 | CAS number: 68815-47-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Both main constituents of the submission substance (BHMT and HMD) were assessed separately for acute fish toxicity. HMD proved to be of very low acute toxicity to fish with an LC50 (96 h) of 1825 mg/L. For BHMT the determined LC50 (48 h) was 76 mg/L, but the alkaline properties of the test item were not taken into account and toxicity due to alkaline pH is likely. However, this conservative value is taken as decisive for acute fish toxicity of the submission substance.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 76 mg/L
Additional information
Both main constituents of the submission substance (BHMT and HMD) were assessed separately for acute fish toxicity.
The study on HMD (according to OECD 203, reliability category 2) with fathead minnow (Pimephales promelas) resulted in a LC50 (96 h) of 1825 mg/L (95% CI = 1237-2461 mg/L; Probit analysis). No effects were observed up to a nominal concentration of 1000 mg/L. Very high concentrations up to 10 000 mg/L have been tested and pH of the stock solution was adjusted to pH 8-8.5. No analytical verification of test item concentration were performed, however the HMD-fraction of the submission substance has been shown to be completely stable under similar testing conditions in the invertebrates toxicity test (IUCLID section 6.1.3, KS_Rhodia_Harlan_D54670_2012_Short-term toxicity to aquatic invertebrates).
The study on BHMT with Golden ide (Leuciscus idus melanotus) was performed similar to OECD 203 (48 hour exposure, compliant to GLP, reliability category 2). Ten animals were exposed to various concentrations of the test substance in water (static test design).
After evaluation of the results with a "Probit"-method, the following toxicity data were obtained:
NOEC / LC0 (48h): 58 mg/L
LC50 (48 h): 76 mg/L
LC100 (48 h): 100 mg/L
No sublethal effects were observed. The alkaline properties of the test item were not taken into account and toxicity due to alkaline pH is likely. Thus, inherent toxicity of the test item is probably considerably lower and observed toxicity values may be taken as worst case and most probably overestimate toxicity of the test item.
However, the conservative effect value from BHMT is taken as decisive for acute fish toxicity of the submission substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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